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DNA/RNA Synthesis

DNA and RNA synthesis inhibitors interfere with nucleic acid replication or transcription by distinct mechanisms. Platinum compounds such as cisplatin, carboplatin and oxaliplatin form DNA adducts, mainly crosslinks between adjacent guanines on the same strand. These adducts block DNA replication and transcription and trigger DNA damage responses. Mitomycin C also crosslinks DNA, but only after reductive activation inside cells. Gemcitabine, a deoxycytidine analog, is incorporated into DNA as its triphosphate and halts chain elongation. CX-5461 acts on transcription, inhibiting synthesis of ribosomal RNA by RNA polymerase I. The protein synthesis inhibitor cycloheximide, which blocks translation elongation on eukaryotic ribosomes, is listed here as well.

4 Items

  • DNA crosslinker 3 dihydrochloride
    Cat. No.
    A37352
    CAS No.
    2761734-21-6

    DNA crosslinker 3 dihydrochloride

    DNA Crosslinker 3 Dihydrochloride is a potent DNA minor groove binder known for its strong binding affinity, characterized by a ΔTm of 1.4 °C. This reagent is valuable in cancer research, facilitating the study of DNA-protein interactions and potential therapeutic applications. It is suitable for applications involving anticancer drug development and the investigation of genomic stability.

    In stock View Details
    25 mg
    $1,655.00
    50 mg
    $2,115.00
    All 3 sizes
  • DNA crosslinker 4 dihydrochloride
    Cat. No.
    A37353
    CAS No.
    2761734-23-8

    DNA crosslinker 4 dihydrochloride

    DNA Crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder that selectively interacts with DNA strands, resulting in crosslinking. This compound exhibits significant inhibitory activity against cancer cell lines, including NCI-H460, A2780, and MCF-7. It serves as a valuable tool for anticancer research, facilitating investigations into DNA-targeted therapies and elucidating mechanisms of action in cancer biology.

    In stock View Details
    25 mg
    $1,655.00
    50 mg
    $2,115.00
    All 3 sizes
  • DNA crosslinker 1 dihydrochloride
    Cat. No.
    A37354
    CAS No.
    2761734-27-2

    DNA crosslinker 1 dihydrochloride

    DNA crosslinker 1 dihydrochloride functions as a potent DNA minor groove binder, exhibiting a DNA binding affinity characterized by a ΔTm of 1.1 °C. This compound is particularly relevant in cancer research, facilitating the study of DNA interactions and mechanisms involved in tumorigenesis. Its ability to modulate DNA architecture makes it a valuable tool for investigating anticancer therapies and molecular biology applications.

    In stock View Details
    25 mg
    $1,655.00
    50 mg
    $2,115.00
    All 3 sizes
  • Lexitropsin 1
    Cat. No.
    A37375
    CAS No.
    123725-00-8

    Lexitropsin 1

    Lexitropsin 1 is a potent DNA minor groove binder, exhibiting a delta G of 65 kJ/mol at 303 K. This compound demonstrates significant antiviral activity, making it a valuable tool for research in virology and molecular biology. Its ability to selectively interact with DNA enables exploration of gene regulation and cellular processes, expanding the understanding of antiviral mechanisms at the molecular level.

    In stock View Details
    25 mg
    $1,780.00
    50 mg
    $2,280.00
    All 3 sizes

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