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RNA/DNA Polymerase

RNA and DNA polymerase inhibitors block enzymes that copy nucleic acid templates in bacteria, viruses and human cells. Rifampin and rifabutin are rifamycins that bind bacterial RNA polymerase and stop the transcript after two or three nucleotides. For RNA viruses, favipiravir serves as a prodrug whose triphosphate form blocks the viral RNA-dependent RNA polymerase. Tenofovir and abacavir block reverse transcriptase, the DNA polymerase of human immunodeficiency virus (HIV). Actinomycin D intercalates into DNA and blocks transcription, and BMH-21 inhibits RNA polymerase I. Fludarabine phosphate, a purine nucleoside analog, inhibits the human DNA polymerases α and δ.

1 Item

  • NCI-B16
    Cat. No.
    A51082
    CAS No.
    802835-01-4

    NCI-B16

    NCI-B16 is a small molecule that serves as an RNA binder, specifically targeting hepatitis C virus (HCV) RNA. This compound exhibits significant antiviral activity by inhibiting HCV viral replication, making it a valuable tool for studying HCV replication mechanisms and developing therapeutic strategies against hepatitis C. Researchers may utilize NCI-B16 in virology and molecular biology applications to explore RNA-targeting approaches in viral infections.

    In stock View Details
    5 mg
    $410.00
    10 mg
    $670.00
    All 2 sizes

1 Item

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