MTH1

Cat. No.

A37982

CAS No.

2803422-60-6

MTH1 activator-1

MTH1 activator-1 is a potent activator of MTH1, a critical enzyme involved in the repair of oxidative damage to nucleotide pools. This compound significantly enhances endogenous MTH1 activity, leading to reduced levels of 8-oxo-dG in cellular DNA. MTH1 activator-1 serves as a valuable tool for investigating the cellular and biological implications of enhanced oxidative damage repair, and it may provide insights into strategies for delaying or preventing tumorigenesis.

Cat. No.

A38067

CAS No.

2412985-00-1

aTAG 4531

Synonyms: CFT-4531

aTAG 4531 is a selective MTH1 degrader that exerts its action through the formation of a ternary complex with MTH1, CRBN E3 ligase, and the degrader itself. It displays a DC50 value of 0.28 nM and a Ki value of 1.8 nM, highlighting its potent degradation capability. This compound is valuable for research focused on MTH1 inhibition and subsequent cellular effects, offering insights into its role in cancer biology and related therapeutic applications.

Cat. No.

A38361

CAS No.

2387510-81-6

aTAG 2139

Synonyms: CFT-2139

aTAG 2139 is a selective degrader targeting MTH1 via an aTAG-based mechanism. It demonstrates biological activity with a DC50 value of 1.1 nM and a Ki value of 2.1 nM for MTH1 inhibition. This compound is suitable for studies investigating the role of MTH1 in various cellular processes and therapeutic applications in cancer research.

Cat. No.

A38450

CAS No.

2412987-06-3

MTH1 degrader-1

MTH1 degrader-1 is a potent degrader targeting MTH1 through a PROTAC mechanism. This compound facilitates the selective degradation of MTH1, making it a valuable tool for studying the role of MTH1 in cancer metabolism and therapy resistance. Key applications include the development of PROTACs and the synthesis of related compounds, such as PROTAC aTAG 4531.

Cat. No.

A39260

CAS No.

139307-94-1

8-Oxo-dGTP

Synonyms: 8-Oxo-Deoxyguanosine triphosphate

8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) is a reactive oxidized guanine nucleotide that serves as a substrate for MTH1 and other pyrophosphohydrolases. This compound is known to act as a mutagen, integrating into DNA and leading to A:T to C:G transversions, which can contribute to genomic instability. Additionally, 8-Oxo-dGTP can provoke oxidative DNA modifications, strand breaks, and the promotion of apoptosis, particularly in mth1-deficient organisms. Its accumulation is linked to various biological processes and is extensively utilized in research on carcinogenesis, neurodegenerative diseases, and other pathologies.