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Orphan Nuclear Receptor

Orphan nuclear receptor ligands act on nuclear receptors cloned before a natural ligand was known. The term dates from 1988, when estrogen-related receptors were identified by sequence similarity to the estrogen receptor. Many further superfamily members were found this way, as a 1995 review of the second decade of nuclear receptor research describes. Liver receptor homolog 1 (LRH-1, NR5A2) regulates development, metabolism and steroidogenesis. ML-180 is an LRH-1 inverse agonist, LRH-1 agonist-2 activates the receptor, and RJW100 activates LRH-1 together with steroidogenic factor 1 (SF-1). MI-883 activates and CINPA1 inhibits the constitutive androstane receptor (CAR). The set is mixed and also lists compounds for unrelated targets, such as splicing factor 3B subunit 1 (SF3B1).

2 Items

  • TLX agonist 1
    Cat. No.
    A85364
    CAS No.
    958323-31-4

    TLX agonist 1

    TLX Agonist 1 acts as a modulator for the orphan nuclear receptor TLX (NR2E1), exhibiting an EC50 of 1 μM and a Kd of 650 nM. This compound enhances the transcriptional repressive activity of TLX, making it a valuable tool for research into gene regulation and neurogenesis. Its unique mechanism supports investigations into the role of TLX in various biological processes and potential therapeutic applications.

    In stock View Details
    1 mg
    $25.00
    5 mg
    $60.00
    All 7 sizes
  • NR2F6 modulator-2
    Cat. No.
    A85371
    CAS No.
    22978-55-8

    NR2F6 modulator-2

    NR2F6 modulator-2 is a selective modulator of the orphan nuclear receptor NR2F6, which plays a crucial role in gene regulation and cellular processes. This compound demonstrates the ability to inhibit the recruitment of the bio-NSD1 peptide, with an IC50 value of 2.0 equivalents of NR2F6. NR2F6 modulator-2 is intended for research applications in the fields of cancer biology and immunology, contributing to the understanding of NR2F6's role in various pathophysiological conditions.

    In stock View Details
    1 mg
    $20.00
    5 mg
    $25.00
    All 6 sizes

2 Items

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