We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Apelin Receptors

Apelin receptor agonists and antagonists act on the apelin receptor (APJ, APLNR), a G protein-coupled receptor. The human APJ gene was cloned in 1993 and showed sequence identity with the angiotensin receptor. It remained an orphan receptor until 1998, when apelin was isolated from bovine stomach extracts as its endogenous peptide ligand. A second ligand, Elabela, was described in 2013 as a hormone required for heart development in zebrafish. The list includes Apelin-36(human), Apelin-17(human, bovine), the pyroglutamate form (Glp1)-Apelin-13 and ELA-21 (human). CMF019 and azelaprag are small-molecule agonists, and MM 07 is a cyclic peptide agonist. ML221 serves as a functional APJ antagonist in cell-based assays.

1 Item

  • APJ receptor agonist 10
    Cat. No.
    A59057
    CAS No.
    3037373-19-3

    APJ receptor agonist 10

    APJ Receptor Agonist 10 is a potent modulator of the APJ receptor, primarily involved in the regulation of cardiovascular and fluid homeostasis. This compound demonstrates significant biological activity and is particularly relevant in the study of pulmonary arterial hypertension. Its favorable bioavailability over the free base form enhances its utility in various research applications focused on cardiovascular diseases and related therapeutic targets.

    In stock View Details
    5 mg
    $255.00
    10 mg
    $420.00
    All 2 sizes

1 Item

Added to your cart

View Cart Checkout

    Loading...