- Cat. No.
- A18558
CTPB
CTPB is an activator of p300 HAT (histone acetyltransferase) without PCAF (p300/CBP-associated factor) HAT activities.
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- Cat. No.
- A21018
YF-2
YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.
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- Cat. No.
- A22131
TTK21
TTK21 is a CBP/p300 histone acetyltransferase activator.
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- Cat. No.
- A29189
YF-2 hydrochloride
YF-2 hydrochloride is a selective histone acetyltransferase activator targeting CBP, PCAF, and GCN5 with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM, respectively, while demonstrating no inhibitory effects on HDAC. This compound effectively acetylates histone H3 in the hippocampus and is capable of crossing the blood-brain barrier. YF-2 hydrochloride is primarily utilized in research focused on cancer biology and neurodegenerative diseases, including Alzheimer's disease.
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- Cat. No.
- A29198
SPV106
SPV106 is an activator of histone acetylases (HAT) and GCN5-related N-acetyltransferases (GNAT). This compound enhances the activity of these enzymes, facilitating the acetylation of histones and impacting gene expression. SPV106 is particularly relevant for studies related to type 2 diabetes (T2D), offering insights into the epigenetic mechanisms that may contribute to the disease. Its application may provide valuable information for understanding the role of protein acetylation in metabolic disorders.
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- Cat. No.
- A30034
CTB
CTB is a potent activator of the p300 histone acetyltransferase, known for its role in regulating gene expression through histone acetylation. This compound has demonstrated the ability to induce apoptosis in MCF-7 breast cancer cells, making it a valuable tool for research into cancer biology and therapeutic approaches targeting acetylation pathways. Its specificity for p300 highlights its potential in studies of transcriptional regulation and chromatin dynamics.
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