EPZ-6438 (Tazemetostat)

Name: EPZ-6438 (Tazemetostat)
SKU: A12712
Price: 50 USD
Rating: 5 (3 reviews)

Catalog No.: A12712

EZH2 inhibitor

Adooq's EPZ-6438 (Tazemetostat) has been cited by 3 publications

EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

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Grouped product items
Size	Price	Stock
5mg	$50.00	In stock
10mg	$70.00	In stock
25mg	$90.00	In stock
50mg	$90.00	In stock
*10mM 1mL in DMSO**	$60.00	In stock
Bulk Size	Bulk Discount

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Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

Other Forms of EPZ-6438 (Tazemetostat)

Tazemetostat hydrobromide

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Adooq Products cited in reputable paper

Adooq's EPZ-6438 (Tazemetostat) has been cited by 3 publications

Yang PM, .et al. , Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078

Wang Z, .et al. , J Cell Mol Med, 2019, May 13 PMID: 31087496

Theresa Baker, .et al. , Oncotarget, 2015, Oct 20; 6(32): 32646-32655 PMID: 26360609

Biological Activity

Discription

EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

Targets

Target	Value

Product Information

Catalog Num	A12712
Formula	C34H44N4O4
Molecular Weight	572.74
CAS Number	1403254-99-8
SMILES	CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
Synonyms	EPZ6438, EPZ 6438
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 4 mg/mL (6.98 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.46 mL	87.3 mL	174.6 mL
0.5 mM	3.49 mL	17.46 mL	34.92 mL
1 mM	1.75 mL	8.73 mL	17.46 mL
5 mM	0.35 mL	1.75 mL	3.49 mL

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