Ferroptosis-IN-22 is a selective ferroptosis inhibitor that targets and disrupts the interaction between NCOA4 and ferritin, demonstrating an EC50 of 520 nM and a Kd of 0.78 μM. This compound exhibits potent inhibitory activity against ferroptosis induced by agents such as RSL3, Erastin, ML210, and FIN56, while sparing necrosis and apoptosis pathways. Ferroptosis-IN-22 has shown efficacy in ameliorating acute liver injury induced by Concanavalin A, making it a valuable tool for research in ferroptosis-related diseases.
Ferroptosis-IN-22 is a selective ferroptosis inhibitor that targets and disrupts the interaction between NCOA4 and ferritin, demonstrating an EC50 of 520 nM and a Kd of 0.78 μM. This compound exhibits potent inhibitory activity against ferroptosis induced by agents such as RSL3, Erastin, ML210, and FIN56, while sparing necrosis and apoptosis pathways. Ferroptosis-IN-22 has shown efficacy in ameliorating acute liver injury induced by Concanavalin A, making it a valuable tool for research in ferroptosis-related diseases.
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