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Formycin triphosphate

Catalog No.: A60897
ATP Fluorescent Analog
Formycin triphosphate is a fluorescent analog of ATP, designed to bind to enzyme active sites and exhibit enhanced fluorescence. It acts as an ATP-competitive inhibitor of chicken liver pyruvate carboxylase, enabling the study of ATP-dependent pathways. Additionally, Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC50 of approximately 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC50 of around 100 μM, making it valuable for research in cellular signaling and metabolic regulation.
Formycin triphosphate 16409-13-5 ATP Fluorescent Analog
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionFormycin triphosphate is a fluorescent analog of ATP, designed to bind to enzyme active sites and exhibit enhanced fluorescence. It acts as an ATP-competitive inhibitor of chicken liver pyruvate carboxylase, enabling the study of ATP-dependent pathways. Additionally, Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC50 of approximately 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC50 of around 100 μM, making it valuable for research in cellular signaling and metabolic regulation.
Product Information
Catalog NumA60897
FormulaC10H16N5O13P3
Molecular Weight507.18
CAS Number16409-13-5
SMILESNC1=C2C(C([C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)=NN2)=NC=N1
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