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GNF 5837


TRK inhibitor

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Catalog No. A13730

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GNF 5837 10mg A13730-10

Regular Price: €95.00

Special Price: €85.50

GNF 5837 25mg A13730-25

Regular Price: €180.50

Special Price: €162.45

GNF 5837 50mg A13730-50

Regular Price: €256.50

Special Price: €230.85

GNF 5837 100mg A13730-100

Regular Price: €427.50

Special Price: €384.75

GNF 5837 10mM * 1mL in DMSO A13730-10mM-D

Regular Price: €76.00

Special Price: €68.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.

GNF 5837

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Publications citing Adooq Products
GNF 5837 Citations (3)
  • Tanimizu N, .et al. Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver, Development, 2018, Apr 25;145(9). pii: dev159095 PMID: 29615468
  • Shargh VH, .et al. Gelatin-albumin hybrid nanoparticles as matrix metalloproteinases-degradable delivery systems for breast cancer therapy, Nanomedicine (Lond), 2017, May;12(9):977-989 PMID: 28440712
  • Shargh VH, .et al. Albumin hybrid nanoparticles loaded with tyrosine kinase A inhibitor GNF-5837 for targeted inhibition of breast cancer cell growth and invasion, Int J Pharm, 2016, Dec 30;515(1-2):527-534 PMID: 27793712

Chemical Information

Catalog Num A13730
Actions Inhibitor
M. Wt 535.49
Formula C28H21F4N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1033769-28-6
Synonyms GNF-5837, GNF5837
SMILES CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4

Biological Activity

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
Target Value
TrkCIC50: 7nM
TrkBIC50: 9nM
TrkAIC50: 11nM
PDGFRβIC50: 0.87μM
KitIC50: 0.91μM
JAK2IC50: 2.9μM
ALKIC50: 3.4μM
CSF-1RIC50: 4μM
FLT3IC50: 5.1μM
RETIC50: 5.3μM
MetIC50: 5.8μM
FGFR4IC50: 7μM
SrcIC50: 7.3μM
IGF-1RIC50: 7.6μM
Insulin ReceptorIC50: 8μM
AblIC50: 8.2μM
FGFR3IC50: 9.3μM


Solubility (25°C)* In vitro DMSO 100 mg/mL (186.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL heating (16.8 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.67 mL 93.37 mL 186.74mL
0.5 mM 3.73 mL 18.67 mL 37.35 mL
1 mM 1.87 mL 9.34 mL 18.67 mL
5 mM 0.37 mL 1.87 mL 3.73 mL

*The above data is based on the productmolecular weight 535.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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