HWY-289 is a semisynthetic protoberberine derivative targeting phytopathogenic fungi. It exhibits broad-spectrum activity, particularly effective against Botrytis cinerea with an EC50 of 1.34 μg/mL. HWY-289 alters mycelial morphology and disrupts cellular internal structure, leading to reduced ATP content and ATPase activity, as well as inhibition of key enzymes within the TCA cycle. These properties make HWY-289 a valuable tool for research in fungal physiology and plant pathology.
HWY-289 is a semisynthetic protoberberine derivative targeting phytopathogenic fungi. It exhibits broad-spectrum activity, particularly effective against Botrytis cinerea with an EC50 of 1.34 μg/mL. HWY-289 alters mycelial morphology and disrupts cellular internal structure, leading to reduced ATP content and ATPase activity, as well as inhibition of key enzymes within the TCA cycle. These properties make HWY-289 a valuable tool for research in fungal physiology and plant pathology.
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