I-BET151 dihydrochloride is a selective inhibitor of the bromodomain and extraterminal (BET) family, targeting BRD2, BRD3, and BRD4 with pIC50 values of 6.1, 6.3, and 6.6, respectively. This compound effectively disrupts the interaction between BET proteins and acetylated lysines, leading to a reduction in transcriptional activity of key oncogenes. I-BET151 dihydrochloride is primarily utilized in cancer research and studies related to inflammatory diseases, making it a valuable tool for elucidating the role of BET proteins in various biological processes.
I-BET151 dihydrochloride is a selective inhibitor of the bromodomain and extraterminal (BET) family, targeting BRD2, BRD3, and BRD4 with pIC50 values of 6.1, 6.3, and 6.6, respectively. This compound effectively disrupts the interaction between BET proteins and acetylated lysines, leading to a reduction in transcriptional activity of key oncogenes. I-BET151 dihydrochloride is primarily utilized in cancer research and studies related to inflammatory diseases, making it a valuable tool for elucidating the role of BET proteins in various biological processes.
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