Complement System

Cat. No.

A16946

CAS No.

514814-49-4

PMX-205

PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50 = 31 nM).

Cat. No.

A18905

CAS No.

1644670-37-0

Iptacopan (LNP023)

Synonyms: LNP 023

LNP023 is a highly potent factor B (FB) inhibitor with an IC50 value of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human FB (KD=7.9 nM).

Cat. No.

A13968

CAS No.

344897-95-6

Leukadherin 1

Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM).

Cat. No.

A18512

CAS No.

1646682-14-5

FD-IN-1

FD-IN-1 (Compound 12) is a factor D (FD) inhibitor with an IC50 of 12 nM.

Cat. No.

A18609

CAS No.

1903768-17-1

Danicopan

Synonyms: ACH-4471

Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM.

Cat. No.

A18864

CAS No.

2365402-67-9

Complement C5-IN-1

Complement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5).

Cat. No.

A20253

CAS No.

1386455-76-0

Complement factor D-IN-1

Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC50s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.

Cat. No.

A21347

CAS No.

1140525-25-2

SB290157 trifluoroacetate

Synonyms: SB 290157

SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM.

Cat. No.

A22732

CAS No.

206645-99-0

Compstatin

Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates' complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively.

Cat. No.

A22779

CAS No.

1789738-04-0

AMY-101 TFA

Synonyms: Cp40 TFA

AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.

Cat. No.

A22799

CAS No.

934461-40-2

POT-4 (AL-78898A)

Synonyms: AL-78898A

POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research

Cat. No.

A24350

CAS No.

2411440-41-8

JR14a

JR14a is a potent thiophene-based antagonist of the human complement C3a receptor (C3aR). It exhibits high selectivity for C3aR over the C5a receptor and effectively suppresses C3aR-mediated inflammatory responses. JR14a is a valuable tool for studying the role of C3aR in immune regulation and inflammation-related diseases.

Cat. No.

A24462

CAS No.

1349637-14-4

CP-289,503

CP-289,503 is an inhibitor of the complement C5a receptor, with an IC₅₀ of 1 μM. The C5a receptor mediates pro-inflammatory signaling by binding to C5a, a complement activation product that stimulates leukocyte and phagocyte activation, upregulates integrins, and induces degranulation of inflammatory cells, contributing to endothelial damage. By blocking C5a signaling, CP-289,503 may be useful in the treatment of various inflammatory diseases.

Cat. No.

A24463

CAS No.

2797066-85-2

Lanoracopan

Lanoracopan is a potent inhibitor of complement factor B, with an IC₅₀ of 1.2 μM. It is suitable for research in inflammation- and immunity-related diseases.

Cat. No.

A24464

CAS No.

2378381-06-5

Tarvicopan

Tarvicopan is an inhibitor for complement factor D.

Cat. No.

A24465

CAS No.

125228-51-5

L-156602

Synonyms: Antibiotic L 156602; PD 124966

L-156602 is a C5a receptor antagonist that inhibits inflammation and blocks the migration of monocytes and neutrophils to sites of infiltration in mouse inflammatory models. It also suppresses the efferent phase of delayed-type hypersensitivity (DTH).

Cat. No.

A24467

CAS No.

1356469-36-7

PIC1 PA

PIC1 PA is a 15-amino-acid peptide and a potent analog of PIC1 that inhibits classical pathway–mediated complement activation. It functions by disrupting the interaction between C1s-C1r-C1r-C1s/MASPs and the collagen-like region (CLR) of C1q or MBL. PIC1 PA specifically binds to the CLR of C1q, with a mean equilibrium dissociation constant (K\_D) of 33.3 nM for purified C1q.

Cat. No.

A24469

CAS No.

1092847-21-6

CP-447697

CP-447697 is a lipophilic C5a receptor antagonist with an IC₅₀ value of 31 nM. It is suitable for research related to inflammation and complement system modulation.

Cat. No.

A24470

CAS No.

2243483-63-6

Zoracopan

Zoracopan is a selective inhibitor of complement factor D (CFD). Upon systemic administration (oral or intravenous), it preferentially accumulates in ocular tissues and is released in a sustained manner, primarily targeting the choroid–retinal pigment epithelium (C-RPE) and/or iridociliary body (I-CB).

Cat. No.

A24473

CAS No.

2378380-49-3

Pelecopan (BCX9930)

Synonyms: BCX9930

Pelecopan (BCX9930) is a potent, selective, and orally active inhibitor of complement factor D, with an IC₅₀ value of 14.3 nM. It targets factor D to prevent both intravascular and extravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) and is also applicable to other diseases mediated by the alternative complement pathway.

Cat. No.

A24479

CAS No.

405098-33-1

W-54011

W-54011 is a potent, orally active, non-peptide antagonist of the C5a receptor. It inhibits the binding of \[¹²⁵I]-labeled C5a to human neutrophils with a Kᵢ of 2.2 nM. W-54011 also suppresses C5a-induced intracellular Ca²⁺ mobilization, chemotaxis, and reactive oxygen species (ROS) generation in human neutrophils, with IC₅₀ values of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.

Cat. No.

A24480

CAS No.

2086178-00-7

Vemircopan (ALXN2050)

Synonyms: ACH 0145228; ACH-5228; ALXN2050

Vemircopan (ALXN2050) is an orally active inhibitor of complement factor D (FD). It is being investigated for the treatment of complement-mediated diseases, including myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria (PNH).

Cat. No.

A24482

CAS No.

1567836-70-7

Perforin-IN-2

Perforin-IN-2 (Compound 1) is a perforin inhibitor that blocks perforin-mediated cell lysis. It has potential to reduce graft rejection in the context of allogeneic bone marrow or stem cell transplantation.

Cat. No.

A24483

CAS No.

2749438-61-5

EG01377 dihydrochloride

EG01377 dihydrochloride is a potent, bioavailable, and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM and IC₅₀ values of 609 nM for both NRP1-a1 and NRP1-b1 domains. It exhibits antiangiogenic, antimigratory, and antitumor activities.

Cat. No.

A24484

CAS No.

1254036-23-1

JPE-1375

JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist that effectively inhibits polymorphonuclear leukocyte mobilization with an EC₅₀ of 6.9 µM and reduces TNF levels with an EC₅₀ of 4.5 µM in mice. It is suitable for research in autoimmune and inflammatory diseases.