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IKZF Family

IKZF degraders remove Ikaros family zinc finger (IKZF) transcription factors of lymphocytes. Ikaros (IKZF1) was cloned in 1992 as an early lymphoid-specific transcription factor linked to T cell commitment. In 2014, two studies showed that lenalidomide recruits IKZF1 and Aiolos (IKZF3) to the cereblon (CRBN) E3 ubiquitin ligase for degradation. Lenalidomide hemihydrate, FPFT-2216 and MGD-28 act through this molecular glue mechanism. DEG-77 degrades Helios (IKZF2) together with casein kinase 1 alpha (CK1α). The section also holds cereblon-recruiting proteolysis targeting chimeras (PROTACs) such as BSJ-03-204, which degrades cyclin-dependent kinases 4 and 6 (CDK4, CDK6).

1 Item

  • AG6033
    Cat. No.
    A32009
    CAS No.
    329706-62-9

    AG6033

    AG6033 is a novel modulator of the cereblon (CRBN) protein. This compound effectively suppresses various tumor cell lines by influencing the interactions between CRBN and key antitumor target proteins, leading to the degradation of GSPT1 and IKZF1. AG6033 has demonstrated a CRBN-dependent cytotoxic effect, making it a valuable tool for research in cancer biology and the development of targeted therapies.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

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