NOD-like Receptor (NLR)

Cat. No.

A25365

CAS No.

3069891-88-6

NLRP3 modulator 8

NLRP3 Modulator 8 is a selective modulator targeting the NLRP3 inflammasome, exhibiting a DC50 of 9 nM for NEK7 degradation. It effectively inhibits caspase-1 activity and IL-1β release in macrophages, demonstrating dose-dependent effects upon NLRP3 activation. This compound is valuable for research into autoinflammatory and autoimmune diseases, such as multiple sclerosis and Alzheimer's disease, as well as cardiovascular and metabolic disorders, including pericarditis and Type 2 diabetes.

Cat. No.

A35611

CAS No.

2143015-87-4

NLRP3 modulator 1

NLRP3 Modulator 1 is a selective modulator targeting the NLRP3 inflammasome. This compound functions as an agonist or partial agonist, effectively enhancing NLRP3 activity. It is valuable for research into conditions, diseases, or disorders where reduced NLRP3 activity plays a role in disease pathology, facilitating studies on inflammation and immune responses.

Cat. No.

A35652

CAS No.

676656-93-2

(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA

Synonyms: (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-coenzyme A

(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA is a modulator of NLRX1, a member of the NLR family involved in the regulation of immune responses. This compound plays a significant role in the study of immune and metabolic disorders, offering insights into potential therapeutic mechanisms. Its unique structure facilitates research into cellular processes related to inflammation and metabolism.