Catalog No.: A10478

Topoisomerase I inhibitor


Irinotecan Chemical Structure

CAS NO. 97682-44-5

Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.

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100 mg

Regular Price: $60.00

Special Price $48.00

200 mg

Regular Price: $100.00

Special Price $80.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • T Kannathasan, .et al. Chemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the GNL3L and NF-κB Pathway, Cancers (Basel), 2020, May; 12(5): 1231 PMID: 32422901
  • Gils Jose, .et al. Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy, Cancers (Basel), 2020, Oct 31;12(11):E3211 PMID: 33142721

Biological Activity

Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
Topo I (LoVo, HT-29 cells)
In vitro (25°C) DMSO 6 mg/mL (10.23 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.04 mL 85.22 mL 170.44 mL
0.5 mM 3.41 mL 17.04 mL 34.09 mL
1 mM 1.7 mL 8.52 mL 17.04 mL
5 mM 0.34 mL 1.7 mL 3.41 mL

*The above data is based on the productmolecular weight 586.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10478
Actions Inhibitor
CAS No. 97682-44-5
Formula C33H38N4O6
M. Wt 586.7
Purity >98%
Synonyms Camptosar, CPT-11
SMILES CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[[email protected]@]5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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