Tivozanib (AV-951)

Catalog No.: A10101

VEGFR Inhibitor

Tivozanib (AV-951)

Tivozanib (AV-951) Chemical Structure

CAS NO. 475108-18-0

Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.

Availability: In stock

Package Price Qty
5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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  • Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298
  • Majid Momeny, .et al. Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells, Sci Rep, 2017, 7: 45954 PMID: 28383032
  • Majid Momeny, .et al. Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells, Sci Rep, 2017, 7: 44075 PMID: 28287096
  • Nicholas A. Manieri, .et al. Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis, J Clin Invest, 2015, Sep 1; 125(9): 3606-3618 PMID: 26280574
  • Usui T, .et al. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells., Acta Physiol (Oxf), 2014, 211, 385-394 PMID: 24612679

Biological Activity

Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.
Target Value
VEGFR2IC50: 6.5nM
VEGFR3IC50: 15nM
EphB2IC50: 24nM
VEGFR1IC50: 30nM
PDGFRαIC50: 40nM
PDGFRβIC50: 49nM
c-KitIC50: 78nM
Tie-2IC50: 78nM
EphB4IC50: 480nM
FGFR1IC50: 530nM
c-MetIC50: 550nM
AblIC50: 620nM
SrcIC50: 960nM
FGFR3IC50: >1μM
FGFR4IC50: >1μM
FLT3IC50: >1μM
EGFRIC50: >1μM
ErbB2IC50: >1μM
Insulin ReceptorIC50: >1μM
FAKIC50: >1μM
ErbB4IC50: >1μM
IGF-1RIC50: >1μM
JAK2IC50: >1μM
In vitro (25°C) DMSO 19 mg/mL (41.76 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.98 mL 109.91 mL 219.83 mL
0.5 mM 4.4 mL 21.98 mL 43.97 mL
1 mM 2.2 mL 10.99 mL 21.98 mL
5 mM 0.44 mL 2.2 mL 4.4 mL

*The above data is based on the productmolecular weight 454.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10101
Actions Inhibitor
CAS No. 475108-18-0
Formula C22H19ClN4O5
M. Wt 454.9
Purity >98%
Synonyms AV-951, AV951

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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