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Tivozanib (AV-951)


VEGFR Inhibitor

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Catalog No. A10101

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Tivozanib 5mg A10101-5

Regular Price: $40.00

Special Price: $36.00

Tivozanib 10mg A10101-10

Regular Price: $70.00

Special Price: $63.00

Tivozanib 25mg A10101-25

Regular Price: $120.00

Special Price: $108.00

Tivozanib 50mg A10101-50

Regular Price: $180.00

Special Price: $162.00

Tivozanib (AV-951) 10mM * 1mL in DMSO A10101-10mM-D

Regular Price: $95.00

Special Price: $85.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.

Tivozanib (AV-951)

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Publications citing Adooq Products
Tivozanib (AV-951) Citations (4)
  • Majid Momeny, .et al. Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells, Sci Rep, 2017, 7: 45954 PMID: 28383032
  • Majid Momeny, .et al. Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells, Sci Rep, 2017, 7: 44075 PMID: 28287096
  • Nicholas A. Manieri, .et al. Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis, J Clin Invest, 2015, Sep 1; 125(9): 3606-3618 PMID: 26280574
  • Usui T, .et al. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells., Acta Physiol (Oxf), 2014, 211, 385-394 PMID: 24612679

Chemical Information

Catalog Num A10101
Actions Inhibitor
M. Wt 454.9
Formula C22H19ClN4O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 475108-18-0
Synonyms AV-951, AV951

Biological Activity

Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.
Target Value
VEGFR2IC50: 6.5nM
VEGFR3IC50: 15nM
EphB2IC50: 24nM
VEGFR1IC50: 30nM
PDGFRαIC50: 40nM
PDGFRβIC50: 49nM
c-KitIC50: 78nM
Tie-2IC50: 78nM
EphB4IC50: 480nM
FGFR1IC50: 530nM
c-MetIC50: 550nM
AblIC50: 620nM
SrcIC50: 960nM
FGFR3IC50: >1μM
FGFR4IC50: >1μM
FLT3IC50: >1μM
EGFRIC50: >1μM
ErbB2IC50: >1μM
Insulin ReceptorIC50: >1μM
FAKIC50: >1μM
ErbB4IC50: >1μM
IGF-1RIC50: >1μM
JAK2IC50: >1μM


Solubility (25°C) * In vitro DMSO 20 mg/mL (43.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.98 mL 109.91 mL 219.83mL
0.5 mM 4.4 mL 21.98 mL 43.97 mL
1 mM 2.2 mL 10.99 mL 21.98 mL
5 mM 0.44 mL 2.2 mL 4.4 mL

*The above data is based on the productmolecular weight 454.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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