Tivozanib (AV-951)

Catalog No.: A10101

VEGFR Inhibitor

Tivozanib (AV-951) Chemical Structure

CAS NO. 475108-18-0

Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $32.00

10 mg

Regular Price: $70.00

Special Price $56.00

25 mg

Regular Price: $120.00

Special Price $96.00

50 mg

Regular Price: $180.00

Special Price $144.00

10mM * 1mL in DMSO
$95.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.
Targets
Target Value
VEGFR2IC50: 6.5nM
VEGFR3IC50: 15nM
EphB2IC50: 24nM
VEGFR1IC50: 30nM
PDGFRαIC50: 40nM
PDGFRβIC50: 49nM
c-KitIC50: 78nM
Tie-2IC50: 78nM
EphB4IC50: 480nM
FGFR1IC50: 530nM
c-MetIC50: 550nM
AblIC50: 620nM
SrcIC50: 960nM
FGFR3IC50: >1μM
FGFR4IC50: >1μM
FLT3IC50: >1μM
EGFRIC50: >1μM
ErbB2IC50: >1μM
Insulin ReceptorIC50: >1μM
FAKIC50: >1μM
ErbB4IC50: >1μM
IGF-1RIC50: >1μM
JAK2IC50: >1μM
In vitro (25°C) DMSO 20 mg/mL (43.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.98 mL 109.91 mL 219.83 mL
0.5 mM 4.4 mL 21.98 mL 43.97 mL
1 mM 2.2 mL 10.99 mL 21.98 mL
5 mM 0.44 mL 2.2 mL 4.4 mL

*The above data is based on the productmolecular weight 454.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10101
Actions Inhibitor
M. Wt 454.9
Formula C22H19ClN4O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 475108-18-0
Synonyms AV-951, AV951
SMILES CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl

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