KRAS G12C Inhibitor 48 is a potent inhibitor targeting the KRAS G12C mutation, with an IC50 of 639.91 nM. This compound demonstrates significant anti-proliferative activity in various cancer cell lines, exhibiting IC50 values of 0.796 µM in H358, 6.33 µM in H23, and 16.14 µM in A549 cells. It serves as a valuable tool for research into KRAS-driven malignancies and therapeutic strategies targeting mutant KRAS.
KRAS G12C Inhibitor 48 is a potent inhibitor targeting the KRAS G12C mutation, with an IC50 of 639.91 nM. This compound demonstrates significant anti-proliferative activity in various cancer cell lines, exhibiting IC50 values of 0.796 µM in H358, 6.33 µM in H23, and 16.14 µM in A549 cells. It serves as a valuable tool for research into KRAS-driven malignancies and therapeutic strategies targeting mutant KRAS.
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