KRAS-IN-48 is a selective inhibitor targeting KRAS mutations, exhibiting Kd values of 2.58 nM for the KRAS-G12D variant and 5.49 μM for KRAS-G12V. This compound demonstrates significant biological activity against KRAS mutant proteins, making it an important tool in cancer research. KRAS-IN-48 is particularly valuable for studies focused on understanding the role of KRAS mutations in tumorigenesis and therapeutic response.
KRAS-IN-48 is a selective inhibitor targeting KRAS mutations, exhibiting Kd values of 2.58 nM for the KRAS-G12D variant and 5.49 μM for KRAS-G12V. This compound demonstrates significant biological activity against KRAS mutant proteins, making it an important tool in cancer research. KRAS-IN-48 is particularly valuable for studies focused on understanding the role of KRAS mutations in tumorigenesis and therapeutic response.
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