Fatty Acids & Derivatives

Cat. No.

A29175

CAS No.

116912-55-1

Crotonyl-CoA tetralithium

Crotonyl-CoA tetralithium is a high-energy acyl donor and an important derivative of CoA involved in the metabolism of fatty acids and amino acids. It serves as a substrate for p300's histone crotonyltransferase activity, influencing global and gene-specific histone crotonylation levels, and plays a role in the regulation of gene expression. Additionally, Crotonyl-CoA tetralithium is utilized in the NADPH-mediated reduction and carbon dioxide trapping catalyzed by crotonyl-CoA reductase/carboxylase, contributing to the formation of alkylmalonyl-CoA polyketide synthase extender units. This compound is valuable for studies related to the LPS-induced inflammatory response.

Cat. No.

A60851

CAS No.

1609382-32-2

Resolvin D5 n-3 DPA

Resolvin D5 n-3 DPA is a specialized proresolving lipid mediator derived from docosapentaenoic acid. It acts as an agonist for GPR101, GPR12, and GPR84, displaying EC50 values of 4.6 pM, 14 pM, and 1.5 pM, respectively. This compound exhibits potent anti-inflammatory and pro-resolution properties, effectively reducing cell adhesion on TNF-α-activated human endothelial monolayers. Furthermore, Resolvin D5 n-3 DPA enhances leukocyte functions, promoting the phagocytic activity of neutrophils and macrophages, making it valuable in research related to intestinal inflammation.

Cat. No.

A67842

CAS No.

745-64-2

Prostaglandin F3α

Synonyms: PGF3α

Prostaglandin F3α (PGF3α) is a bioactive lipid mediator derived from eicosapentaenoic acid (EPA) known for its anti-cancer and anti-inflammatory properties. It functions as a substrate for the ATP-binding cassette transporter ABCC4, exhibiting a Km of 12.1 μM. PGF3α is particularly relevant for research involving metabolic conditions, including diabetes, offering insights into its underlying mechanisms and potential therapeutic targets.

Cat. No.

A71314

CAS No.

6610-25-9

Arachidonic acid sodium salt

Synonyms: Immunocytophyt sodium salt

Arachidonic acid sodium salt is a polyunsaturated omega-6 fatty acid primarily involved in cellular membrane structure. As a crucial substrate for the synthesis of lipid mediators, including prostaglandins, this compound plays a significant role in inflammatory responses and various physiological processes. Research applications encompass studies in neurobiology and cardiovascular health, highlighting its impact on cognitive function and cardiovascular performance.

Cat. No.

A73176

CAS No.

852043-48-2

Tetradecyl-CoA triammonium

Tetradecyl-CoA triammonium is a long-chain acyl-CoA molecule that serves as a key substrate in fatty acid metabolism. This compound plays a critical role in various metabolic pathways, including lipid biosynthesis and energy production. It is commonly utilized in research applications investigating acyl-CoA signaling mechanisms and the regulation of fatty acid oxidation.

Cat. No.

A73686

CAS No.

9035-51-2

Cytochrome P450

Cytochrome P450 refers to a family of monooxygenase enzymes that facilitate the conversion of fatty acids into terminal alkenes through the utilization of hydrogen peroxide as a co-substrate. As membrane-bound hemoproteins, these enzymes are integral to various biological processes, including drug detoxification, cellular metabolism, and maintenance of homeostasis. Their study is crucial for understanding metabolic pathways and responses to environmental changes, making them valuable reagents for pharmacological and biochemical research applications.

Cat. No.

A74080

CAS No.

79171-47-4

(S)-3-Hydroxyhexanoyl-CoA

Synonyms: L-3-Hydroxyhexanoyl-CoA

(S)-3-Hydroxyhexanoyl-CoA is a hydroxy fatty acyl-CoA that plays a crucial role in fatty acid metabolism. It functions as a substrate for various enzymatic reactions involved in the biosynthesis and degradation of fatty acids. This compound is particularly relevant in studies focused on lipid metabolism, mitochondrial function, and metabolic disorders. It serves as an important reagent for researchers investigating the roles of hydroxy fatty acids in cellular processes.

Cat. No.

A74362

CAS No.

111004-08-1

9(S)-HpOTrE

9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid generated through the action of 5-lipoxygenase on α-linolenic acid. It exhibits key biological activities as a substrate for further oxidation, leading to the formation of 9,16-dihydroperoxy acid. Additionally, 9(S)-HpOTrE can be metabolized into colnelenic acid by divinyl ether synthase, typically found in garlic and potato microsomes. This compound is valuable in research applications focused on lipid biochemistry and the study of oxidative signaling pathways.

Cat. No.

A87630

CAS No.

29743-97-3

cis-10-Heptadecenoic acid

Cis-10-Heptadecenoic acid is a cis-fatty acid that serves as a substrate for the synthesis of polyhydroxy-chain alkanoates, mediated by enzymes such as 2,4-dienyl-CoA reductase and Delta3, Delta2-enyl-CoA isomerase. This compound plays a significant role in lipid metabolism and may be utilized in research focused on fatty acid biosynthesis, bioengineering of microbial systems, and the development of bioplastics. Its unique structural properties make it a valuable reagent for studies in lipid biochemistry and metabolic engineering applications.

Cat. No.

A92019

CAS No.

2260795-80-8

28:0 Coenzyme A ammonium

28:0 Coenzyme A ammonium is a saturated fatty acyl-CoA derivative that plays a critical role in lipid metabolism. It is involved in fatty acid synthesis and degradation pathways, serving as a substrate for various enzymatic reactions in cellular metabolism. This reagent is essential for research applications focused on lipid biochemistry and metabolic studies.

Cat. No.

A98136

CAS No.

13487-46-2

Arachidonyl alcohol

Arachidonyl alcohol is a long-chain primary fatty alcohol that serves as a substrate for the synthesis of various ether lipids. These ether lipids are known to exhibit beneficial biological functions, making arachidonyl alcohol valuable in studies related to lipid metabolism and cellular signaling. Its applications extend to research in areas such as inflammation, cell differentiation, and neurobiology, providing insight into the role of ether lipids in health and disease.

Cat. No.

B20171

CAS No.

155205-99-5

17-Phenyl trinor prostaglandin F2α isopropyl amide

17-Phenyl trinor prostaglandin F2α isopropyl amide is a derivative of 17-phenyl trinor prostaglandin F2α, primarily targeting lipid signaling pathways. This compound exhibits significant activity as an EP1 receptor agonist, influencing renal function and contributing to conditions such as glomerulosclerosis. It serves as a valuable tool in the study of prostaglandin-related biological mechanisms and renal pathophysiology.

Cat. No.

B20362

CAS No.

176108-52-4

18-Oxooctadecanoic acid

18-Oxooctadecanoic acid is a long-chain fatty acid derivative that serves as a substrate for P450BM-3, leading to the oxidative transformation into the corresponding α,ω-dicarboxylic acid, 1,18-octadecanedioic acid. This compound does not undergo decarboxylation, preventing the formation of one-carbon-shortened olefins. It is valuable for investigating the metabolic pathways associated with aldehyde-containing long-chain fatty acids, facilitating research into fatty acid metabolism and its implications in various biological processes.