Cytochrome P450

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  1. Veledimex

    Catalog No. A21011
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    CYP3A4/5 inhibitor and substrate
    Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5. Learn More
  2. Haloperidol (Haldol)

    Catalog No. A10446
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    CYP2D6 inhibitor
    Haloperidol (Haldol) is an antipsychotic and butyrophenone. Learn More
  3. Efavirenz

    Catalog No. A15826
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    cytochrome P450 inhibitor
    Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Learn More
  4. Clarithromycin

    Catalog No. A10225
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    cytochrome P4503A4 inhibitor
    Clarithromycin is a macrolide antibiotic. It prevents bacteria from growing by interfering with their protein synthesis. Learn More
  5. Sulfaphenazole

    Catalog No. A17283
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    CYP2C9 inhibitor
    Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Learn More
  6. CYP17-IN-1

    Catalog No. A12622
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    CYP17 inhibitor
    CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM. Learn More
  7. Seviteronel

    Catalog No. A20996
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    CYP17 lyase inhibitor
    Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. Learn More
  8. Talarozole R enantiomer

    Catalog No. A13113
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    Cytochrome P450 inhibitor
    Talarozole R enantiomer inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. Learn More
  9. Liarozole dihydrochloride

    Catalog No. A21853
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    CYP450 dependent inhibitor
    Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). Learn More
  10. Bergaptol

    Catalog No. A12303
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    CYP3A4 enzyme inhibitor
    Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties. Learn More
  11. Clotrimazole

    Catalog No. A10234
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    Action of clotrimazole is against the division and growing of fungi.Clotrimazole alters the permeability of the fungal cell wall and inhibits the activity of enzymes within the cell. It specifically inhibits the biosynthesis of ergosterol and other sterols required for cell membrane production. Learn More
  12. Ozagrel(OKY-046)

    Catalog No. A10688
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    TXAS inhibitor
    Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. Learn More
  13. PF 4981517

    Catalog No. A12544
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    CYP3A4 inhibitor
    PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively). Learn More
  14. Hydroxyflutamide (Hydroxyniphtholide)

    Catalog No. A11865
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    Hydroxyflutamide (Hydroxyniphtholide) is a metabolite of flutamide found to inhibit the proliferation of estradiol-induced growth of MCF-7 breast cancer cells. Learn More
  15. Chloramphenicol

    Catalog No. A10200
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    Chloramphenicol is a bacteriostatic antimicrobial. Learn More
  16. Methoxsalen (Oxsoralen)

    Catalog No. A10578
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    Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Learn More
  17. Itraconazole (Sporanox)

    Catalog No. A10489
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    Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Learn More
  18. Deferasirox

    Catalog No. A10293
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    Iron chelator
    Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Learn More
  19. TMS

    Catalog No. A11977
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    TMS is a potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50= 6 nM). 5N/A- and 520-fold selective over P450 1A1 and 1A2 respectively. Learn More
  20. ABT

    Catalog No. A13361
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    Cytochrome P450 inhibitor
    ABT (1-Aminobenzotriazole )is a suicide substrate for (CYP)cytochrome P-450 and chloroperoxidase. Learn More
  21. Chlorzoxazone

    Catalog No. A16449
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    Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1. Learn More
  22. Benzbromarone

    Catalog No. A16201
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    CYP2C9 inhibitor
    Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM. Learn More
  23. Azathramycin

    Catalog No. A15010
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    CYP3A4 Inhibitor
    Azithromycin, derived from erythromycin, is a antibiotic. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. Learn More
  24. Choline Fenofibrate

    Catalog No. A15044
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    CYP2C19/CYP2B6 inhibitor
    Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. Learn More
  25. Luliconazole

    Catalog No. A11481
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    Luliconazole is an azole antifungal indicated for the topical treatment of interdigital tinea pedis. Learn More
  26. TAK-700 Salt (Orteronel Salt)

    Catalog No. A13515
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    CYP17A1/androgen synthesis inhibitor
    Orteronel (TAK700) is an androgen synthesis inhibitor. It selectively inhibits the enzyme CYP17A which is expressed in testicular, adrenal, and prostatic tumor tissues. Learn More
  27. Methoxyresorufin

    Catalog No. A13367
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    cytochrome P450 substrate
    Methoxyresorufin is a fluorometric substrate for cytochrome P450 linked enzymes. Learn More
  28. Mephenytoin

    Catalog No. A13366
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    CYP2C19 and CYP2B6 substrate
    Mephenytoin is a CYP2C19 substrate. Anticonvulsant. Learn More
  29. 3-Cyano-7-ethoxycoumarin

    Catalog No. A13365
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    Fluorescent P450 substrate
    3-Cyano-7-ethoxycoumarin is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. It is a fluorescent probe useful in microsomal dealkylase studies. Learn More
  30. Cobicistat (GS-9350)

    Catalog No. A11277
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    CYP3A Inhibitor
    Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Learn More
  31. Alizarin

    Catalog No. A10054
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    CYP17 inhibitor
    Alizarin is novelly used as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color. Learn More
  32. Posaconazole

    Catalog No. A10744
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    CYP3A4 inhibitor
    Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours. Learn More
  33. Baicalein

    Catalog No. A10120
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    Lipoxygenase Inhibitor

    Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 µM.

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  34. Apigenin

    Catalog No. A10081
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    Protein kinase inhibitor

    Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.

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  35. Cyproterone acetate

    Catalog No. A11409
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    Androgen Receptor antagonist
    Cyproterone acetate is a synthetic derivative of 17-hydroxyprogesterone, and acts as an androgen receptor antagonist as well as a weak progesterone receptor agonist with weak progestational and glucocorticoid activity. Learn More
  36. Sodium Danshensu

    Catalog No. A10853
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    Sodium danshensu is a sodium salt of danshensu from the widely used Chinese herb Danshen (Salvia miltiorrhiza Bunge). In vitro and in vivo studies revealed that danshensu possessed diverse pharmacological effects, including relaxation of coronary artery, anticoagulation, protection of myocardial ischemia-reperfusion injury, and antiarrhythmia activities Learn More
  37. Naringenin

    Catalog No. A10625
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    Naringenin is a flavanone, a type of flavonoid, that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Learn More
  38. TH-302 (Evofosfamide)

    Catalog No. A11144
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    TH-302 is a selectively targeting hypoxic regions of solid tumors hypoxia-activated prodrug. Learn More
  39. TOK-001 (Galeterone)

    Catalog No. A11138
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    CYP17 inhibitor
    TOK-001 (Galeterone) is both an androgen receptor antagonist and CYP17A1 inhibitor. Learn More
  40. Avasimibe (CI-1011)

    Catalog No. A10102
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    CYP17 inhibitor
    Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. Learn More
  41. Abiraterone Acetate (CB7630)

    Catalog No. A11058
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    CYP17 inhibitor
    Abiraterone acetate (CB7630) is an orally active acetate ester of the steroidal compound Abiraterone with antiandrogen activity. Abiraterone inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1). Learn More
  42. Abiraterone (CB-7598)

    Catalog No. A10020
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    CYP17 inhibitor
    Abiraterone (CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues. Learn More
  43. Voriconazole (Vfend)

    Catalog No. A10978
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    CYP17 inhibitor
    Voriconazole (Vfend) is a triazole antifungal agent that is available as a lyophilized powder for solution for intravenous infusion. Learn More
  44. TAK-700 (Orteronel)

    Catalog No. A11044
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    CYP17A1 inhibitor
    TAK-700 (Orteronel) is an oral, non-steroidal androgen synthesis inhibitor that selectively inhibits the 17,20 lyase enzyme. Learn More
  45. Ketoconazole

    Catalog No. A10498
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    P450 inhibitor
    As an antifungal, ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, a constituent of fungal cell membranes, as well as certain enzymes. Learn More
  46. Cytochrome P450 14a-demethylase inhibitor 1c

    Catalog No. A10269
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  47. Cytochrome P450 14a-demethylase inhibitor 1n

    Catalog No. A10280
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  48. Cytochrome P450 14a-demethylase inhibitor 1m

    Catalog No. A10279
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  49. Cytochrome P450 14a-demethylase inhibitor 1L

    Catalog No. A10278
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  50. Cytochrome P450 14a-demethylase inhibitor 1k

    Catalog No. A10277
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