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$0.00 Cytochrome P450
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Clarithromycin
Catalog No. A10225 cytochrome P4503A4 inhibitorClarithromycin is a macrolide antibiotic. It prevents bacteria from growing by interfering with their protein synthesis. Learn More -
Veledimex
Catalog No. A21011 CYP3A4/5 inhibitor and substrateVeledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5. Learn More -
Seviteronel
Catalog No. A20996 CYP17 lyase inhibitorSeviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. Learn More -
Liarozole dihydrochloride
Catalog No. A21853 CYP450 dependent inhibitorLiarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). Learn More -
Bergaptol
Catalog No. A12303 CYP3A4 enzyme inhibitorBergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties. Learn More -
CYP17-IN-1
Catalog No. A12622 CYP17 inhibitorCYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM. Learn More -
Sulfaphenazole
Catalog No. A17283 CYP2C9 inhibitorSulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Learn More -
Efavirenz
Catalog No. A15826 cytochrome P450 inhibitorEfavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Learn More -
Talarozole R enantiomer
Catalog No. A13113 Cytochrome P450 inhibitorTalarozole R enantiomer inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase. Learn More -
Haloperidol (Haldol)
Catalog No. A10446 CYP2D6 inhibitorHaloperidol (Haldol) is an antipsychotic and butyrophenone. Learn More -
Luliconazole
Catalog No. A11481 Luliconazole is an azole antifungal indicated for the topical treatment of interdigital tinea pedis. Learn More -
TMS
Catalog No. A11977 TMS is a potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50= 6 nM). 5N/A- and 520-fold selective over P450 1A1 and 1A2 respectively. Learn More -
Sodium Danshensu
Catalog No. A10853 Sodium danshensu is a sodium salt of danshensu from the widely used Chinese herb Danshen (Salvia miltiorrhiza Bunge). In vitro and in vivo studies revealed that danshensu possessed diverse pharmacological effects, including relaxation of coronary artery, anticoagulation, protection of myocardial ischemia-reperfusion injury, and antiarrhythmia activities Learn More -
Methoxsalen (Oxsoralen)
Catalog No. A10578 Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Learn More -
Hydroxyflutamide (Hydroxyniphtholide)
Catalog No. A11865 Hydroxyflutamide (Hydroxyniphtholide) is a metabolite of flutamide found to inhibit the proliferation of estradiol-induced growth of MCF-7 breast cancer cells. Learn More -
PF 4981517
Catalog No. A12544 CYP3A4 inhibitorPF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively). Learn More -
Ozagrel(OKY-046)
Catalog No. A10688 TXAS inhibitorOzagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. Learn More -
Naringenin
Catalog No. A10625 Naringenin is a flavanone, a type of flavonoid, that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Learn More -
ABT
Catalog No. A13361 Cytochrome P450 inhibitorABT (1-Aminobenzotriazole )is a suicide substrate for (CYP)cytochrome P-450 and chloroperoxidase. Learn More -
3-Cyano-7-ethoxycoumarin
Catalog No. A13365 Fluorescent P450 substrate3-Cyano-7-ethoxycoumarin is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. It is a fluorescent probe useful in microsomal dealkylase studies. Learn More -
Mephenytoin
Catalog No. A13366 CYP2C19 and CYP2B6 substrateMephenytoin is a CYP2C19 substrate. Anticonvulsant. Learn More -
Methoxyresorufin
Catalog No. A13367 cytochrome P450 substrateMethoxyresorufin is a fluorometric substrate for cytochrome P450 linked enzymes. Learn More -
TAK-700 Salt (Orteronel Salt)
Catalog No. A13515 CYP17A1/androgen synthesis inhibitorOrteronel (TAK700) is an androgen synthesis inhibitor. It selectively inhibits the enzyme CYP17A which is expressed in testicular, adrenal, and prostatic tumor tissues. Learn More -
Itraconazole (Sporanox)
Catalog No. A10489 Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Learn More -
Choline Fenofibrate
Catalog No. A15044 CYP2C19/CYP2B6 inhibitorCholine Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. Learn More -
Azathramycin
Catalog No. A15010 CYP3A4 InhibitorAzithromycin, derived from erythromycin, is a antibiotic. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. Learn More -
Alizarin
Catalog No. A10054 CYP17 inhibitorAlizarin is novelly used as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color. Learn More -
Benzbromarone
Catalog No. A16201 CYP2C9 inhibitorBenzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM. Learn More -
Chlorzoxazone
Catalog No. A16449 Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1. Learn More -
TH-302 (Evofosfamide)
Catalog No. A11144 TH-302 is a selectively targeting hypoxic regions of solid tumors hypoxia-activated prodrug. Learn More -
TOK-001 (Galeterone)
Catalog No. A11138 CYP17 inhibitorTOK-001 (Galeterone) is both an androgen receptor antagonist and CYP17A1 inhibitor. Learn More -
Avasimibe (CI-1011)
Catalog No. A10102 CYP17 inhibitorAvasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. Learn More -
Abiraterone Acetate (CB7630)
Catalog No. A11058 CYP17 inhibitorAbiraterone acetate (CB7630) is an orally active acetate ester of the steroidal compound Abiraterone with antiandrogen activity. Abiraterone inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1). Learn More -
Abiraterone (CB-7598)
Catalog No. A10020 CYP17 inhibitorAbiraterone (CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues. Learn More -
Voriconazole (Vfend)
Catalog No. A10978 CYP17 inhibitorVoriconazole (Vfend) is a triazole antifungal agent that is available as a lyophilized powder for solution for intravenous infusion. Learn More -
Deferasirox
Catalog No. A10293 Iron chelatorDeferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Learn More -
Apigenin
Catalog No. A10081 Protein kinase inhibitorApigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.
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Baicalein
Catalog No. A10120 Lipoxygenase InhibitorBaicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 µM.
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Posaconazole
Catalog No. A10744 CYP3A4 inhibitorPosaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours. Learn More -
Ketoconazole
Catalog No. A10498 P450 inhibitorAs an antifungal, ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, a constituent of fungal cell membranes, as well as certain enzymes. Learn More -
Cobicistat (GS-9350)
Catalog No. A11277 CYP3A InhibitorCobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Learn More -
Cyproterone acetate
Catalog No. A11409 Androgen Receptor antagonistCyproterone acetate is a synthetic derivative of 17-hydroxyprogesterone, and acts as an androgen receptor antagonist as well as a weak progesterone receptor agonist with weak progestational and glucocorticoid activity. Learn More -
Clotrimazole
Catalog No. A10234 Action of clotrimazole is against the division and growing of fungi.Clotrimazole alters the permeability of the fungal cell wall and inhibits the activity of enzymes within the cell. It specifically inhibits the biosynthesis of ergosterol and other sterols required for cell membrane production. Learn More -
TAK-700 (Orteronel)
Catalog No. A11044 CYP17A1 inhibitorTAK-700 (Orteronel) is an oral, non-steroidal androgen synthesis inhibitor that selectively inhibits the 17,20 lyase enzyme. Learn More
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