Sphingolipids

Cat. No.

A30052

CAS No.

124753-97-5

C6 Ceramide

Synonyms: C6-Cer; N-Hexanoylsphingosine

C6 Ceramide is a short-chain, cell-permeable ceramide pathway activator that exhibits significant anticancer activity. It enhances miR-29b expression, influencing the progression of multiple myeloma by inhibiting endothelial cell proliferation, migration, and angiogenesis through the Akt signaling pathway. C6 Ceramide demonstrates a range of anti-cancer effects, including cell cycle arrest, induction of apoptosis, and tumor growth inhibition, and can serve as an adjuvant to improve the effectiveness of chemotherapy in drug-resistant cancer cells.

Cat. No.

A30101

CAS No.

63335-25-1

Malabaricone C

Malabaricone C is a noncompetitive inhibitor of sphingomyelin synthase (SMS), demonstrating IC50 values of 3 μM for SMS 1 and 1.5 μM for SMS 2. This compound has been shown to reduce body weight gain, enhance glucose tolerance, and decrease hepatic lipid accumulation, effectively preventing high-fat diet-induced fatty liver in murine models. Additionally, Malabaricone C exhibits anti-inflammatory properties, making it a valuable tool for research into obesity and immune disorders linked to T-cell hyperactivation. Its source is the fruit of Myristica cinnamomea King.

Cat. No.

A30871

CAS No.

306301-68-8

SKI-I

SKI-I is a selective inhibitor of human sphingosine kinase (SK), exhibiting an IC50 of 1.2 μM for ST-hSK. In addition to its primary action, SKI-I also inhibits hERK2 with an IC50 of 11 μM. This compound demonstrates the ability to induce apoptosis in various tumor cell lines, making it a valuable tool for exploring sphingosine kinase's role in cancer biology and therapeutic research.

Cat. No.

A52544

CAS No.

139974-41-7

DL-threo-PPMP hydrochloride

DL-threo-PPMP hydrochloride is a specific inhibitor of sphingosine synthetase in Plasmodium falciparum. By mimicking sphingosine, it effectively inhibits the enzyme's activity, leading to a reduction in sphingomyelin synthase activity and disrupting the parasite's cytoplasmic tubular network. This mechanism not only hampers the proliferation of the malaria parasite but also offers insights into malaria biology and the development of novel antimalarial therapies.

Cat. No.

A53002

CAS No.

149022-18-4

DL-threo-PPMP

DL-threo-PPMP is a potent inhibitor of sphingosine synthetase in Plasmodium falciparum, effectively mimicking the substrate sphingosine to disrupt enzymatic activity. This inhibition leads to a significant reduction in sphingosine synthetase function, resulting in the dismantling of the tubular network of Toxoplasma gondii vacuoles within host cells, thereby hindering the proliferation of the parasite. DL-threo-PPMP serves as a valuable tool for investigating Plasmodium biology and developing novel antimalarial strategies.

Cat. No.

B18200

CAS No.

1045857-53-1

XM462

XM462 is a potent inhibitor of dihydroceramide desaturase, demonstrating mixed-type inhibition with a Ki value of 2 μM in vitro. This compound exhibits effective inhibition of dihydroceramide desaturase in both in vitro assays and cultured cells, with IC50 values of 8.2 μM and 0.78 μM, respectively. XM462 is relevant for research applications focused on tumor biology and lipid metabolism.

Cat. No.

B19067

CAS No.

649767-83-9

(1R,2S)-Deoxy-PR280

(1R,2S)-Deoxy-PR280 is a competitive inhibitor of dihydroceramide desaturase, exhibiting an inhibition constant (Ki) of 6 µM. This compound is essential for studying sphingolipid metabolism and related signaling pathways. Its inhibitory action provides valuable insights into cellular processes, making it applicable in research on cancer, neurodegeneration, and metabolic diseases.

Cat. No.

B20701

CAS No.

1407154-31-7

cis-4-Methylsphingosine

Cis-4-Methylsphingosine is a synthetic analogue of sphingosine that functions as a modulator of sphingosine-1-phosphate receptors. It exhibits key biological activities related to cell signaling, particularly influencing pathways involved in cell proliferation and survival. This compound is utilized in research applications focused on lipid signaling, inflammation, and cancer biology, making it a valuable tool for studying the roles of sphingolipids in various physiological processes.

Cat. No.

B21015

CAS No.

1246298-61-2

N-C24:1-Desoxymethylsphinganine

N-C24:1-desoxymethylsphinganine is a potent inhibitor of sphingolipid metabolism, targeting key enzymes involved in the biosynthesis and degradation of sphingolipids. This compound is important for research applications focusing on lipid signaling pathways and their implications in various diseases, including cancer and neurodegeneration. By studying N-C24:1-desoxymethylsphinganine, researchers can gain insights into the role of sphingolipids in cellular processes and therapeutic interventions.