Sphingolipids

Cat. No.

A30101

CAS No.

63335-25-1

Malabaricone C

Malabaricone C is a noncompetitive inhibitor of sphingomyelin synthase (SMS), demonstrating IC50 values of 3 μM for SMS 1 and 1.5 μM for SMS 2. This compound has been shown to reduce body weight gain, enhance glucose tolerance, and decrease hepatic lipid accumulation, effectively preventing high-fat diet-induced fatty liver in murine models. Additionally, Malabaricone C exhibits anti-inflammatory properties, making it a valuable tool for research into obesity and immune disorders linked to T-cell hyperactivation. Its source is the fruit of Myristica cinnamomea King.

Cat. No.

A30871

CAS No.

306301-68-8

SKI-I

SKI-I is a selective inhibitor of human sphingosine kinase (SK), exhibiting an IC50 of 1.2 μM for ST-hSK. In addition to its primary action, SKI-I also inhibits hERK2 with an IC50 of 11 μM. This compound demonstrates the ability to induce apoptosis in various tumor cell lines, making it a valuable tool for exploring sphingosine kinase's role in cancer biology and therapeutic research.

Cat. No.

A52544

CAS No.

139974-41-7

DL-threo-PPMP hydrochloride

DL-threo-PPMP hydrochloride is a specific inhibitor of sphingosine synthetase in Plasmodium falciparum. By mimicking sphingosine, it effectively inhibits the enzyme's activity, leading to a reduction in sphingomyelin synthase activity and disrupting the parasite's cytoplasmic tubular network. This mechanism not only hampers the proliferation of the malaria parasite but also offers insights into malaria biology and the development of novel antimalarial therapies.

Cat. No.

A53002

CAS No.

149022-18-4

DL-threo-PPMP

DL-threo-PPMP is a potent inhibitor of sphingosine synthetase in Plasmodium falciparum, effectively mimicking the substrate sphingosine to disrupt enzymatic activity. This inhibition leads to a significant reduction in sphingosine synthetase function, resulting in the dismantling of the tubular network of Toxoplasma gondii vacuoles within host cells, thereby hindering the proliferation of the parasite. DL-threo-PPMP serves as a valuable tool for investigating Plasmodium biology and developing novel antimalarial strategies.

Cat. No.

A65539

CAS No.

752987-57-8

Biotinylated sphingosine

Synonyms: Biotinyl-Sph

Biotinylated sphingosine is a substrate for sphingosine kinase, primarily targeting SPHK1 and SPHK2. This compound enables the detection of sphingosine kinase phosphorylation activity, making it a valuable tool for studies focused on sphingolipid metabolism and signal transduction pathways. Researchers can leverage biotinylated sphingosine in various applications, including enzyme activity assays and the exploration of sphingosine-related cellular processes.

Cat. No.

B18200

CAS No.

1045857-53-1

XM462

XM462 is a potent inhibitor of dihydroceramide desaturase, demonstrating mixed-type inhibition with a Ki value of 2 μM in vitro. This compound exhibits effective inhibition of dihydroceramide desaturase in both in vitro assays and cultured cells, with IC50 values of 8.2 μM and 0.78 μM, respectively. XM462 is relevant for research applications focused on tumor biology and lipid metabolism.

Cat. No.

B19067

CAS No.

649767-83-9

(1R,2S)-Deoxy-PR280

(1R,2S)-Deoxy-PR280 is a competitive inhibitor of dihydroceramide desaturase, exhibiting an inhibition constant (Ki) of 6 µM. This compound is essential for studying sphingolipid metabolism and related signaling pathways. Its inhibitory action provides valuable insights into cellular processes, making it applicable in research on cancer, neurodegeneration, and metabolic diseases.

Cat. No.

B21015

CAS No.

1246298-61-2

N-C24:1-Desoxymethylsphinganine

N-C24:1-desoxymethylsphinganine is a potent inhibitor of sphingolipid metabolism, targeting key enzymes involved in the biosynthesis and degradation of sphingolipids. This compound is important for research applications focusing on lipid signaling pathways and their implications in various diseases, including cancer and neurodegeneration. By studying N-C24:1-desoxymethylsphinganine, researchers can gain insights into the role of sphingolipids in cellular processes and therapeutic interventions.