ML262 is a potent inhibitor of hepatic lipid droplet formation, with an IC50 of 6.4 nM in murine AML-12 cells. This compound is significant in research related to non-alcoholic fatty liver disease, as it selectively targets lipid metabolism without inducing cytotoxicity at concentrations up to 33 μM. Additionally, ML262 does not interfere with fatty acid uptake at concentrations up to 50 μM, making it a valuable tool for studying lipid homeostasis and related metabolic disorders.
ML262 is a potent inhibitor of hepatic lipid droplet formation, with an IC50 of 6.4 nM in murine AML-12 cells. This compound is significant in research related to non-alcoholic fatty liver disease, as it selectively targets lipid metabolism without inducing cytotoxicity at concentrations up to 33 μM. Additionally, ML262 does not interfere with fatty acid uptake at concentrations up to 50 μM, making it a valuable tool for studying lipid homeostasis and related metabolic disorders.
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