Moveltipril calcium is an orally active inhibitor of angiotensin-converting enzyme (ACE), demonstrating significant antihypertensive effects. It forms a stable thioester bond, exhibiting relative resistance to hydrolysis in liver homogenates. Moveltipril calcium effectively inhibits ACE activity extracted from rabbit lung in a concentration-dependent manner. Additionally, it selectively inhibits the contractile response to angiotensin-I in rat aortic rings and guinea pig ileum preparations, while enhancing the response to calcitonin, making it valuable for research in cardiovascular pharmacology and hypertension.
Moveltipril calcium is an orally active inhibitor of angiotensin-converting enzyme (ACE), demonstrating significant antihypertensive effects. It forms a stable thioester bond, exhibiting relative resistance to hydrolysis in liver homogenates. Moveltipril calcium effectively inhibits ACE activity extracted from rabbit lung in a concentration-dependent manner. Additionally, it selectively inhibits the contractile response to angiotensin-I in rat aortic rings and guinea pig ileum preparations, while enhancing the response to calcitonin, making it valuable for research in cardiovascular pharmacology and hypertension.
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