MRTX849 ethoxypropanoic acid is a targeted protein ligand-linker conjugate designed for the selective degradation of KRAS G12C. This compound incorporates a specific ligand that binds to KRAS G12C and a PROTAC linker, facilitating the synthesis of PROTAC LC-2, an innovative compound known for its ability to degrade endogenous KRAS G12C with IC50 values ranging from 0.25 to 0.76 µM. MRTX849 ethoxypropanoic acid is essential for research applications focused on targeted protein degradation and cancer therapeutics involving KRAS mutations.
MRTX849 ethoxypropanoic acid is a targeted protein ligand-linker conjugate designed for the selective degradation of KRAS G12C. This compound incorporates a specific ligand that binds to KRAS G12C and a PROTAC linker, facilitating the synthesis of PROTAC LC-2, an innovative compound known for its ability to degrade endogenous KRAS G12C with IC50 values ranging from 0.25 to 0.76 µM. MRTX849 ethoxypropanoic acid is essential for research applications focused on targeted protein degradation and cancer therapeutics involving KRAS mutations.
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