MS4322 (isomer) is a specific degrader of the protein arginine methyltransferase 5 (PRMT5), exhibiting a DC50 of 1.1 μM for reducing PRMT5 protein levels in MCF-7 cells. It inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM, facilitating ubiquitination and subsequent degradation of the target protein. This reagent is valuable for researching breast cancer, lung cancer, and hepatocellular carcinoma, allowing for exploration of PRMT5's role in tumorigenesis.
MS4322 (isomer) is a specific degrader of the protein arginine methyltransferase 5 (PRMT5), exhibiting a DC50 of 1.1 μM for reducing PRMT5 protein levels in MCF-7 cells. It inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM, facilitating ubiquitination and subsequent degradation of the target protein. This reagent is valuable for researching breast cancer, lung cancer, and hepatocellular carcinoma, allowing for exploration of PRMT5's role in tumorigenesis.
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