NF-κB

Cat. No.

A31617

CAS No.

1398053-45-6

Avadomide hydrochloride

Synonyms: CC 122 hydrochloride

Avadomide hydrochloride is an oral cereblon modulator that targets cereblon E3 ligase activity. By inhibiting the NF-κB signaling pathway and arresting the cell cycle at the G1 phase, it effectively induces apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. This compound demonstrates significant antitumor and immunomodulatory properties, making it a valuable reagent for cancer research applications.

Cat. No.

A31847

CAS No.

3100147-71-2

MMH-165-26

MMH-165-26 is a ligand targeting RelA/p65, playing a crucial role in modulating nuclear factor kappa B (NF-κB) signaling. This compound significantly reduces the expression levels of RelA/p65 and exhibits notable cytotoxicity in MEC-1 cells, with an LC50 of 0.37 μM. MMH-165-26 is a valuable tool for the development of proteolysis-targeting chimeras (PROTACs), such as JP-163-16, enhancing its utility in cancer research and therapeutic applications.

Cat. No.

A34772

CAS No.

15769-56-9

Guluronic acid

Synonyms: G2013

Guluronic acid is an oxidative stress modulator and anti-inflammatory agent. It functions by down-regulating pro-inflammatory genes such as TLR4, NF-κB, and iNOS, while inhibiting COX-2, MMPs, and VEGF activity. This compound promotes the up-regulation of immunoregulatory genes including SHIP1 and SOCS1, thereby mitigating cancer-related inflammation, tumor angiogenesis, cell adhesion, and metastasis, while decreasing immunosuppressive cell accumulation. Guluronic acid has demonstrated potential in extending survival times in tumor-bearing hosts within a non-cytotoxic concentration range and has applications in research related to multiple sclerosis, ankylosing spondylitis, breast cancer, and other inflammatory diseases.

Cat. No.

A56990

CAS No.

163136-19-4

Cannabisin F

Cannabisin F is a modulator of SIRT1, derived from hempseed lignanamide. It exhibits significant anti-inflammatory and antioxidant properties, making it a valuable candidate for research focused on neurodegenerative diseases. Cannabisin F may influence critical pathways involving SIRT1, NF-κB, and Nrf2, contributing to its potential therapeutic applications.

Cat. No.

A64062

CAS No.

2868357-11-1

Glucocorticoid receptor modulator 1

Glucocorticoid receptor modulator 1 is a selective non-steroidal modulator that targets the glucocorticoid receptor, exhibiting potent inhibition of NF-κB and AP-1 with IC50 values of 9 nM and 130 nM, respectively. This compound effectively reduces the expression of key inflammatory cytokines, including IL-6, IL-1β, and TNF-α. Additionally, it demonstrates potential in alleviating dermatitis in preclinical models, making it a valuable tool for research in inflammation and immune response.

Cat. No.

A64067

CAS No.

1008116-73-1

BMS-791826

BMS-791826 is a selective glucocorticoid receptor modulator that targets glucocorticoid receptors to exert its biological effects. This compound effectively inhibits AP-1 and NF-κB-dependent signaling pathways, making it a valuable tool for studying the mechanisms underlying inflammatory diseases. Research applications include the exploration of potential therapeutic strategies for conditions associated with dysregulated glucocorticoid receptor activity.

Cat. No.

A79615

CAS No.

2928463-42-5

IMD-biphenylC

IMD-biphenylC is an imidazoquinolinone-NF-κB modulator that functions through the inhibition of NF-κB signaling pathways. It exhibits significant biological activity by suppressing tumor proliferation while promoting a favorable inflammatory response. This compound is valuable for research applications focused on cancer biology and the modulation of immune responses, particularly in evaluating therapies that minimize systemic inflammation and adjuvant toxicity.

Cat. No.

A79630

CAS No.

2928463-39-0

IMD-catechol

IMD-catechol is a dimeric imidazoquinolinone that functions as a modulator of NF-κB signaling. This compound enhances therapeutic efficacy in models of CT26 colon carcinoma while demonstrating minimal adjuvant toxicity. Its unique mechanism makes it a valuable tool for investigating immune modulation and therapeutic strategies in cancer research.

Cat. No.

A79635

CAS No.

2928463-40-3

IMD-biphenylA

IMD-biphenylA is a novel imidazoquinolinone compound that functions as a modulator of NF-κB activity. This dimeric structure enhances the adjuvanticity of small molecule immune potentiators, making it valuable for research in immunology and therapeutic applications targeting immune responses. Its ability to influence NF-κB signaling pathways positions it as a significant reagent for exploring immune modulation and adjuvant mechanisms.

Cat. No.

A79643

CAS No.

2928463-41-4

IMD-biphenylB

IMD-biphenylB is a potent NF-κB modulator known for its ability to inhibit tumor proliferation. This imidazoquinolinone dimer also demonstrates a capacity to induce low systemic inflammation and minimize adjuvant toxicity. It serves as a valuable tool for research focused on immune response modulation and cancer therapy development.

Cat. No.

A79656

CAS No.

2928463-38-9

IMD-vanillin

IMD-vanillin is an NF-κB modulator that functions as a novel immunomodulatory compound derived from imidazoquinolinone dimers. This reagent has demonstrated the ability to inhibit NF-κB activation, thereby modulating inflammatory responses and influencing cell survival. IMD-vanillin is suitable for research applications focused on inflammation, autoimmune diseases, and cancer, where NF-κB pathways play a crucial role.