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ONC212 is a fluorinated-ONC201 analogue, shows preclinical efficacy in melanoma and hepatocellular-cancer models. ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib.
| In vitro | DMSO | 85 mg/mL (192.98 mM) | |
| Water | Insoluble | ||
| Ethanol | 85 mg/mL (192.98 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.7 mL | 113.52 mL | 227.03 mL |
| 0.5 mM | 4.54 mL | 22.7 mL | 45.41 mL |
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17056 |
|---|---|
| CAS No. | 1807861-48-8 |
| Formula | C24H23F3N4O |
| M. Wt | 440.47 |
| Purity | >98% |
| Synonyms | ONC-212, ONC 212 |
| SMILES | O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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