Impurities & Reference Standards

Cat. No.

A53801

CAS No.

189-55-9

Dibenzo(a,i)pyrene

Dibenzo(a,i)pyrene is a polycyclic aromatic hydrocarbon that serves as a carcinogenic ligand for the TCDD (Ah) receptor. It has been shown to induce DNA adduct formation while upregulating p53 and p21WAF1 protein levels in diploid lung fibroblasts. Additionally, Dibenzo(a,i)pyrene alters cell cycle dynamics, increasing the S phase population and leading to G0/G1 and G2/M phase decreases, resulting in S phase delay or arrest. This compound is relevant for applications in cancer research.

Cat. No.

A65911

CAS No.

319-78-8

D-Isoleucine

Synonyms: (R)-Isoleucine

D-Isoleucine is a selective competitive activator of the Asc-1 antiporter, exhibiting a Ki value of 0.98 mM. By binding to the Asc-1 protein on neuronal cell membranes, D-Isoleucine facilitates the release of D-serine and glycine, thereby enhancing NMDA receptor-dependent synaptic plasticity. This compound is relevant in the study of neurodegenerative diseases, including Alzheimer's disease and schizophrenia. Additionally, D-Isoleucine serves as a non-classical D-amino acid, disrupting bacterial peptidoglycan synthesis and inhibiting biofilm formation in Staphylococcus aureus, suggesting its potential utility in antibacterial research.

Cat. No.

A66546

CAS No.

53108-00-2

(Rac)-Methylindazone

Synonyms: (Rac)-IAA-94

(Rac)-Methylindazone is the racemic mixture of Methylindazone, a potent blocker of the CLIC1 ion channel. This compound exhibits significant biological activity in modulating chloride ion transport, making it a valuable tool in research focused on ion channel function and related physiological processes. Potential applications include studies in cellular signaling and the investigation of CLIC1's role in various pathophysiological conditions.

Cat. No.

A74950

CAS No.

1191996-10-7

(S,S)-Sinogliatin

Synonyms: (S,S)-HMS-5552; (S,S)-RO-5305552

(S,S)-Sinogliatin is the (S,S)-enantiomer of the glucokinase activator Sinogliatin, specifically targeting glucokinase to enhance its activity. This compound demonstrates significant potential in the modulation of glucose metabolism, making it a valuable tool for research applications related to type 2 diabetes. Its use can aid in investigating the therapeutic mechanisms underlying glucose homeostasis and pancreatic function.

Cat. No.

A92742

CAS No.

218-01-9

Chrysene

Chrysene is a high molecular weight polycyclic aromatic hydrocarbon (PAH) recognized for its role as a carcinogenic inducer. This compound exhibits significant potential for inducing malignancies in various biological systems, making it a valuable tool for cancer research. Chrysene is commonly used in studies aimed at elucidating the mechanisms of carcinogenesis and understanding the effects of environmental pollutants on human health.