Impurities & Reference Standards

Cat. No.

A31200

CAS No.

10378-06-0

(6R)-FR054

(6R)-FR054 is a less active isomer of FR054, acting primarily as a modulator of biological pathways influenced by the parent compound. This reagent provides a valuable tool for comparative studies aimed at elucidating the mechanisms of action and specific contributions of the more active isomer. Researchers can utilize (6R)-FR054 in the development of experimental designs that require an understanding of molecular interactions and signaling processes.

Cat. No.

A40166

CAS No.

127810-07-5

WAY-120744

WAY-120744 is a novel naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxide that acts as a potent modulator of biological targets relevant to chemotherapeutic strategies. This compound demonstrates significant anti-cancer activity, making it suitable for applications in cancer research and drug development. Its unique structure permits exploration of mechanisms of action in various cellular contexts, providing valuable insights into the modulation of signaling pathways.

Cat. No.

A53801

CAS No.

189-55-9

Dibenzo(a,i)pyrene

Dibenzo(a,i)pyrene is a polycyclic aromatic hydrocarbon that serves as a carcinogenic ligand for the TCDD (Ah) receptor. It has been shown to induce DNA adduct formation while upregulating p53 and p21WAF1 protein levels in diploid lung fibroblasts. Additionally, Dibenzo(a,i)pyrene alters cell cycle dynamics, increasing the S phase population and leading to G0/G1 and G2/M phase decreases, resulting in S phase delay or arrest. This compound is relevant for applications in cancer research.

Cat. No.

A65911

CAS No.

319-78-8

D-Isoleucine

Synonyms: (R)-Isoleucine

D-Isoleucine is a selective competitive activator of the Asc-1 antiporter, exhibiting a Ki value of 0.98 mM. By binding to the Asc-1 protein on neuronal cell membranes, D-Isoleucine facilitates the release of D-serine and glycine, thereby enhancing NMDA receptor-dependent synaptic plasticity. This compound is relevant in the study of neurodegenerative diseases, including Alzheimer's disease and schizophrenia. Additionally, D-Isoleucine serves as a non-classical D-amino acid, disrupting bacterial peptidoglycan synthesis and inhibiting biofilm formation in Staphylococcus aureus, suggesting its potential utility in antibacterial research.

Cat. No.

A74950

CAS No.

1191996-10-7

(S,S)-Sinogliatin

Synonyms: (S,S)-HMS-5552; (S,S)-RO-5305552

(S,S)-Sinogliatin is the (S,S)-enantiomer of the glucokinase activator Sinogliatin, specifically targeting glucokinase to enhance its activity. This compound demonstrates significant potential in the modulation of glucose metabolism, making it a valuable tool for research applications related to type 2 diabetes. Its use can aid in investigating the therapeutic mechanisms underlying glucose homeostasis and pancreatic function.

Cat. No.

A92742

CAS No.

218-01-9

Chrysene

Chrysene is a high molecular weight polycyclic aromatic hydrocarbon (PAH) recognized for its role as a carcinogenic inducer. This compound exhibits significant potential for inducing malignancies in various biological systems, making it a valuable tool for cancer research. Chrysene is commonly used in studies aimed at elucidating the mechanisms of carcinogenesis and understanding the effects of environmental pollutants on human health.

Cat. No.

B21627

CAS No.

80-75-1

11alpha-Hydroxyprogesterone

11alpha-Hydroxyprogesterone is an isomer of 11beta-Hydroxyprogesterone, serving as a valuable experimental control in research. It exhibits biological activity as a modulator of steroid receptors and can be utilized to investigate the effects of glucocorticoids and mineralocorticoids in cellular systems. Its application includes studying the activation of human mineralocorticoid receptors and the inhibition of 11β-Hydroxysteroid dehydrogenase, facilitating a deeper understanding of steroid hormone signaling pathways.