Oligonucleotide Therapeutics (ASO/siRNA)

Cat. No.: A68428

CAS No.: 2415330-05-9

Zorevunersen sodium

Synonyms: STK-001 sodium

Zorevunersen sodium is an antisense oligonucleotide that acts as an activator of the Scn1a gene through TANGO technology. This compound enhances Scn1a mRNA transcripts, leading to increased expression of the NaV1.1 protein. By restoring the excitability of parvalbumin interneurons, Zorevunersen sodium effectively reduces seizure frequency and improves survival in mouse models. It is a valuable tool for research focused on Dravet syndrome and related epileptic disorders.

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$225.00

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$580.00

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Cat. No.: A68669

CAS No.: 2415330-04-8

Zorevunersen

Synonyms: STK-001

Zorevunersen is an antisense oligonucleotide that acts as an activator of the Scn1a gene through TANGO technology. It enhances the production of Scn1a mRNA transcripts, leading to an increased expression of the NaV1.1 protein. This compound has demonstrated the ability to restore the excitability of parvalbumin interneurons, effectively reducing seizure activity and improving survival rates in murine models. Zorevunersen is a valuable tool for research focused on Dravet syndrome and related channelopathies.

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Cat. No.: A74928

CAS No.: 2131025-83-5

Cimdelirsen sodium

Synonyms: ISIS 766720 sodium; IONIS-GHR-LRx sodium

Cimdelirsen sodium is an investigative antisense oligonucleotide designed to inhibit growth hormone receptor (GHR) synthesis through a ligand-conjugated, hepatic-targeted mechanism. This compound effectively reduces the detrimental effects associated with growth hormone (GH) hypersecretion and lowers circulating insulin-like growth factor-1 (IGF-1) levels in patients with acromegaly. Its primary applications include studying the modulation of GH signaling and exploring therapeutic strategies in disorders related to GH excess.

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