PFI-2

Catalog No.: A14216

SETD7 inhibitor

PFI-2

PFI-2 Chemical Structure

CAS NO. 1627676-59-8

PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

Availability: In stock

Package Price Qty
10 mg
$100.00
25 mg
$200.00
50 mg
$350.00
10mM * 1mL in DMSO
$105.00
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Biological Activity

PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Targets
SETD7 SETD7
0.33 nM(Ki)2 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.02 mL 100.1 mL 200.19 mL
0.5 mM 4 mL 20.02 mL 40.04 mL
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 499.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14216
Actions Inhibitor
CAS No. 1627676-59-8
Formula C23H25F4N3O3S
M. Wt 499.52
Purity >98%
Synonyms PFI2
SMILES C1CCN(C1)C(=O)[[email protected]@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC(=C4CNCCC4=C3)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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