PFI-2

Catalog No.: A14216

SETD7 inhibitor

PFI-2 Chemical Structure

CAS NO. 1627676-59-8

PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

Availability: In stock

Package Price Qty
10 mg
$100.00
25 mg
$200.00
50 mg
$350.00
10mM * 1mL in DMSO
$105.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Targets
SETD7 SETD7
0.33 nM(Ki)2 nM
In vitro DMSO 99 mg/mL (198.19 mM)
Water 4 mg/mL heating (8.0 mM)
Ethanol 66 mg/mL heating (132.12 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.02 mL 100.1 mL 200.19 mL
0.5 mM 4 mL 20.02 mL 40.04 mL
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 499.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14216
Actions Inhibitor
M. Wt 499.52
Formula C23H25F4N3O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1627676-59-8
Synonyms PFI2
SMILES C1CCN(C1)C(=O)[[email protected]@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC(=C4CNCCC4=C3)F

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