Proteasome

Cat. No.

A77300

CAS No.

90468-18-1

Z-Ala-Arg-Arg-AMC

Synonyms: Fluorogenic Proteasome Substrate; Z-ARR-AMC

Z-Ala-Arg-Arg-AMC is a fluorogenic proteasome substrate designed to specifically assay the trypsin-like activity of the proteasome. Its unique structure allows for sensitive detection of proteolytic activity, making it a valuable tool for studying protein degradation and turnover in cellular processes. This substrate is widely utilized in research applications focused on proteasome function and its implications in various diseases.

Cat. No.

A77307

CAS No.

355140-49-7

Ac-Nle-Pro-Nle-Asp-AMC

Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate designed for the 26S proteasome, targeting its catalytic activities. This compound is utilized primarily for assessing the caspase-like activity of the 26S proteasome in various biological studies. Its application is crucial for understanding proteasomal regulation and function in cellular processes.

Cat. No.

A77322

CAS No.

152015-61-7

Z-Leu-Leu-Leu-AMC

Synonyms: Z-LLL-AMC

Z-Leu-Leu-Leu-AMC is a fluorogenic substrate designed for the assessment of chymotrypsin-like protease activity in the 20S proteasome. It provides a sensitive and specific means to monitor proteasomal function and proteolytic activity. This reagent is valuable for research applications involving protein degradation, cellular homeostasis, and the study of proteasome-related diseases.

Cat. No.

A77331

CAS No.

728005-83-2

Calpain substrate

Calpain substrate is a fluorogenic substrate specifically designed for the assessment of calpain enzymatic activity. It is membrane non-permeable, ensuring precise measurement of calpain activity in biological samples. This reagent is suitable for applications in cellular signaling research and studies investigating calpain's role in various physiological and pathological processes.

Cat. No.

A77333

CAS No.

80651-95-2

Suc-Ala-Ala-Pro-Phe-SBzl

Suc-Ala-Ala-Pro-Phe-SBzl is a synthetic peptide substrate targeting rat intestinal mast cell proteases RMCP I and RMCP II, as well as chymotrypsin. It serves as a useful tool for investigating proteolytic activity in biochemical assays. Additionally, Suc-Ala-Ala-Pro-Phe-SBzl can be hydrolyzed by glycine (R208G), facilitating studies on enzyme specificity and catalytic mechanisms. This substrate is valuable in researching mast cell biology and protease functions.

Cat. No.

A77358

CAS No.

87779-49-5

Bz-VGR-AMC

Bz-VGR-AMC is a synthetic substrate specifically designed for the trypsin-like activity of the 20S proteasome. This compound enables the quantification of β2 activity within the proteasome, serving as a valuable tool for researching proteasomal function and regulation. Its application is particularly relevant in studies investigating cellular protein degradation, signaling pathways, and disease mechanisms associated with proteasomal dysregulation.

Cat. No.

A77367

CAS No.

201854-05-9

MeOSuc-Gly-Leu-Phe-AMC

MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate specifically designed for proteasomal activity assays. This compound facilitates the study of proteasome function by serving as a sensitive probe for proteolytic activity. It is particularly useful in research areas focused on protein degradation pathways and cellular regulation mechanisms, providing insights into various biological processes and potential disease states.