BTK

Cat. No.

A34435

CAS No.

2764674-60-2

BTK-IN-14

BTK-IN-14 is a potent Bruton tyrosine kinase (BTK) inhibitor, targeting the BTK signaling pathway involved in B cell antigen receptor (BCR) and Fcγ receptor (FcγR) signaling in B and myeloid cells. This compound is instrumental for the investigation of BTK's role in various pathological conditions, including autoimmune diseases, inflammatory disorders, and certain cancers. Its efficacy makes it a valuable tool for researchers exploring BTK-related therapeutic strategies.

Cat. No.

A34436

CAS No.

1581714-50-2

BTK-IN-20

BTK-IN-20 is a selective Bruton's tyrosine kinase (BTK) inhibitor and a 1H-pyrazolo[3,4-d]pyrimidine derivative. This compound demonstrates significant anti-inflammatory and anticancer properties, making it a valuable tool for investigating BTK's role in B-cell signaling and associated malignancies. BTK-IN-20 is suitable for research applications focusing on cancer biology and inflammation pathways.

Cat. No.

A34437

CAS No.

1841502-36-0

BTK-IN-27

BTK-IN-27 is a potent Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 0.2 nM. It exhibits significant anti-proliferative activity in TMD8 cells, with an IC50 of less than 5 nM. This compound is suitable for research applications in cancer, lymphoma, leukemia, and immunological diseases.

Cat. No.

A34438

CAS No.

1654727-33-9

Midobrutinib

Midobrutinib is a potent Bruton's tyrosine kinase (BTK) inhibitor, demonstrating an IC50 of 0.813 nM. This compound is valuable for examining the role of BTK in various diseases, particularly in cancer research. By inhibiting BTK, Midobrutinib aids in the investigation of cellular signaling pathways involved in malignancies and potential therapeutic interventions.

Cat. No.

A34439

CAS No.

2765852-46-6

BTK-IN-11

BTK-IN-11 is a selective inhibitor of Bruton's tyrosine kinase (BTK), a key enzyme in the signaling pathways of B cell antigen receptors (BCR) and Fcγ receptors (FcγR) in B cells and myeloid cells. Its potent inhibition of BTK makes it a valuable tool for investigating the role of BTK in various disease contexts, particularly autoimmune diseases, inflammatory disorders, and certain cancers. This compound supports research aimed at understanding BTK-mediated signaling and its implications in disease pathogenesis.

Cat. No.

A34440

CAS No.

3020776-77-3

GSTO1-IN-2

GSTO1-IN-2 is a dual covalent inhibitor targeting GSTO1 and Bruton's tyrosine kinase (BTK), demonstrating IC50 values of 441 nM and 6.2 nM, respectively. This compound exhibits potent inhibitory activity, making it a valuable tool for research in oncology and autoimmunity. Its ability to effectively modulate key pathways involved in these biological processes supports investigations into therapeutic applications.

Cat. No.

A34441

CAS No.

2573048-10-7

BTK-IN-22

BTK-IN-22 is a highly selective Bruton's tyrosine kinase (BTK) inhibitor, demonstrating an IC50 value of 0.9 nM. It also effectively inhibits BLK and BMX kinases with IC50 values of 1.4 nM and 1.2 nM, respectively. This compound is valuable for research focused on B-cell malignancies and related signaling pathways, providing a useful tool for exploring the therapeutic potential of BTK inhibition. Its improved kinase selectivity compared to existing inhibitors enhances its utility in biological studies.

Cat. No.

A34442

CAS No.

1374239-71-0

BTK-IN-18

BTK-IN-18 is a potent, reversible Bruton’s Tyrosine Kinase (BTK) inhibitor with an IC50 of 0.002 µM. This compound effectively inhibits the expression of CD69 and CD86 in vivo, demonstrating its potential in modulating B-cell receptor signaling pathways. BTK-IN-18 is suitable for research applications in hematological malignancies and autoimmune diseases, facilitating studies on B cell function and therapy development.

Cat. No.

A34443

CAS No.

2251799-53-6

BTK-IN-41

BTK-IN-41 is a selective Bruton’s tyrosine kinase (BTK) inhibitor with an IC50 value of 5.4 nM. This compound effectively inhibits diffuse large B cell lymphoma cell line TDM-8 with an IC50 of 13.8 nM. BTK-IN-41 is valuable for investigating the role of BTK in B cell malignancies and for evaluating potential therapeutic strategies in hematological cancers.

Cat. No.

A34444

CAS No.

2765854-31-5

BTK-IN-33

BTK-IN-33 is a Bruton’s tyrosine kinase (Btk) inhibitor that demonstrates significant anticancer activity. This compound selectively targets the Btk pathway, which is crucial for B-cell receptor signaling and survival. BTK-IN-33 is primarily utilized in research investigating B-cell malignancies and provides potential therapeutic insights into related cancers.

Cat. No.

A34445

CAS No.

1609465-78-2

PF-303

PF-303 is a highly selective, oral inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 0.64 nM. This compound forms a reversible covalent bond with the Cys481 residue of BTK, allowing for targeted modulation of BTK activity without the concerns associated with irreversible inhibitors. PF-303 is valuable for investigating the role of BTK in immune system functioning, particularly in analyzing B-cell subsets, antibody production, and T-cell activation dynamics.

Cat. No.

A34446

CAS No.

1791400-83-3

BTK-IN-40

BTK-IN-40 is a potent Bruton’s tyrosine kinase (BTK) inhibitor, designed to selectively inhibit BTK activity. This compound exhibits significant anti-inflammatory and anti-proliferative effects, making it a valuable tool for research in autoimmune diseases and hematological malignancies. BTK-IN-40’s targeted action facilitates the exploration of BTK's role in various signaling pathways and its therapeutic potential in related conditions.

Cat. No.

A34447

CAS No.

2759280-09-4

WS-11

WS-11 is a non-covalent reversible inhibitor of Bruton's tyrosine kinase (BTK), exhibiting IC50 values of 3.9 nM and 2.2 nM for wild-type and C481S mutant BTK, respectively. Its potent activity arises from the formation of strong π-π interactions with phenylalanine 540 and p-π interactions with lysine 430 within the active site, complemented by robust hydrogen bonding. WS-11 serves as a valuable tool for studying BTK-related signaling pathways and evaluating therapeutic strategies in disorders such as lymphoma and autoimmune diseases.

Cat. No.

A34449

CAS No.

2762043-61-6

BTK-IN-26

BTK-IN-26 is a highly potent inhibitor of Bruton's tyrosine kinase (BTK), exhibiting IC50 values of 0.7 nM for wild-type BTK and 0.8 nM for the C481S mutant. This compound is suitable for research in cancer and autoimmune diseases, facilitating studies on BTK's role in these conditions. Its selective inhibition allows for effective elucidation of BTK-dependent signaling pathways and therapeutic intervention.

Cat. No.

A34450

CAS No.

3016419-52-3

BTK-IN-34

BTK-IN-34 is a selective Bruton’s Tyrosine Kinase (BTK) inhibitor. It demonstrates significant antiproliferative activity in RAMOS cells by specifically inhibiting phosphorylated BTK (Tyr223), while leaving upstream kinases Lyn and Syk unaffected. This compound is valuable for research into B cell receptor signaling and the development of therapies targeting B cell malignancies.

Cat. No.

A34451

CAS No.

2662512-15-2

Birelentinib

Synonyms: DZD8586

Birelentinib is a potent, selective, non-covalent inhibitor of BTK and LYN tyrosine kinases, effective in penetrating the blood-brain barrier. It demonstrates concentration-dependent antiproliferative activity in RI-1 cells and diffuse large B-cell lymphoma (DLBCL) lines with BTK resistance mutations, such as C481X and V416L. By disrupting both BTK-dependent and independent signaling pathways of the B-cell receptor (BCR), Birelentinib impedes tumor cell proliferation and promotes apoptosis. This compound is valuable in research aimed at overcoming resistance to existing BTK inhibitors in B-cell non-Hodgkin lymphoma (B-NHL).

Cat. No.

A34452

CAS No.

1431727-00-2

BLK-IN-1

BLK-IN-1 is a selective covalent inhibitor targeting B-Lymphoid Tyrosine Kinase (BLK) and Bruton Tyrosine Kinase (BTK), with IC50 values of 18.8 nM and 20.5 nM, respectively. This compound is valuable for investigating the role of these kinases in cancer biology and exploring potential therapeutic applications. Its specificity makes it suitable for studying the molecular mechanisms underlying malignancies associated with BLK and BTK activity.

Cat. No.

A34454

CAS No.

2963606-11-1

HBC-12551

HBC-12551 is a potent orally active Bruton’s tyrosine kinase (BTK) inhibitor, demonstrating an IC50 of 1.31 nM in HEK293 cells for BTK and 2.18 nM for the BTKC481S mutant. This compound exhibits significant antitumor activity, particularly in the context of diffuse large B-cell lymphoma. HBC-12551 serves as a valuable tool for research into targeted therapies for B-cell malignancies.

Cat. No.

A34455

CAS No.

2758596-07-3

BTK-IN-10

BTK-IN-10 is a highly potent Bruton’s Tyrosine Kinase (BTK) inhibitor, exhibiting IC50 values of less than 5 nM against both wild-type BTK and the C481S mutant variant. This compound is ideal for studying BTK signaling pathways and evaluating therapeutic strategies in hematological malignancies. Its efficacy in inhibiting BTK makes it a valuable tool for researchers investigating the role of BTK in immune regulation and cancer biology.

Cat. No.

A34456

CAS No.

1433820-83-7

GNE-431

GNE-431 is a potent, selective, noncovalent pan-BTK inhibitor that targets various BTK mutants, including C481R, T474I, and T474Ms. It demonstrates significant biological activity with an IC50 of 3.2 nM against wild-type BTK and 2.5 nM against the C481S mutant. GNE-431 is a valuable tool for research into hematological disorders and autoimmune diseases, providing insights into the modulation of B-cell signaling pathways.

Cat. No.

A34457

CAS No.

2170788-98-2

BTK-IN-21

BTK-IN-21 is a potent Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 33 nM. It exhibits significant inhibitory effects on BTK activity, making it a valuable tool for research applications related to cancer and autoimmune diseases. This compound enables the exploration of BTK signaling pathways and supports the development of targeted therapies in these areas.

Cat. No.

A34458

CAS No.

2557174-19-1

BTK inhibitor 19

BTK Inhibitor 19 is a highly selective covalent inhibitor of Bruton’s tyrosine kinase (BTK), with an IC50 value of 2.7 nM. This compound effectively modulates BTK activity, playing a crucial role in pathways associated with B cell receptor signaling. It is particularly valuable in research applications focused on B cell malignancies and autoimmune diseases, facilitating the exploration of therapeutic strategies targeting BTK.

Cat. No.

A34459

CAS No.

2155853-43-1

Civorebrutinib

Synonyms: WS-413

Civorebrutinib is a selective inhibitor of Bruton's tyrosine kinase (Btk), which plays a critical role in B cell receptor signaling. This compound exhibits significant antineoplastic activity, making it a valuable tool for research into B cell malignancies and related disorders. Its ability to modulate B cell function positions Civorebrutinib as a candidate for studies examining targeted therapies in hematological cancers.

Cat. No.

A34460

CAS No.

1360055-03-3

RN941

RN941 is a potent Bruton's tyrosine kinase (BTK) inhibitor, targeting the BTK signaling pathway. It exhibits significant biological activity in modulating B-cell signaling, making it a valuable tool in the study of rheumatoid arthritis and B-cell malignancies. RN941 is suitable for research applications involving disease mechanisms and therapeutic strategies in these conditions.

Cat. No.

A34461

CAS No.

2639293-95-9

AMX5160

AMX5160 is an orally active Bruton's tyrosine kinase (BTK) inhibitor, specifically targeting the mutant BTKC481S with an IC50 of 0.98 nM. This reagent is useful for investigating the role of BTK in various malignancies, including leukemia and lymphoma, as well as in research related to multiple sclerosis and other autoimmune disorders.