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GDNF Receptor

Glial cell line-derived neurotrophic factor (GDNF) receptor reagents concern a multicomponent signaling system. GDNF family receptor alpha-1 is a cell surface co-receptor that partners with a receptor tyrosine kinase to transmit signals. This complex is studied in neuronal development and cellular differentiation. Aminoquinol, (E)-aminoquinol and aminoquinol phosphate are assigned here as co-receptor agonists. These entries concern the co-receptor component, making that distinction relevant when selecting compounds for studies of neurotrophic signaling and receptor interactions.

4 Items

  • (E)-Aminoquinol
    Cat. No.
    A84706
    CAS No.
    529507-84-4

    (E)-Aminoquinol

    Synonyms: XIB4035

    (E)-Aminoquinol is a selective agonist of the GFRα-1 receptor. It mimics the neurotrophic effects of glial cell-derived neurotrophic factor (GDNF) and promotes Ret autophosphorylation in Neuro-2A cells. This compound is particularly relevant for research focused on neurodegenerative disorders such as Parkinson’s disease, facilitating studies on neuronal survival and growth pathways.

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    1 mg
    $145.00
    5 mg
    $295.00
    All 2 sizes
  • Aminoquinol
    Cat. No.
    A84707
    CAS No.
    10023-54-8

    Aminoquinol

    Synonyms: (E/Z)-XIB4035

    Aminoquinol is a GFRα-1 agonist that mimics the neurotrophic effects of glial cell line-derived neurotrophic factor (GDNF). It induces Ret autophosphorylation in Neuro-2A cells, promoting neuronal survival and differentiation. This compound is applicable in research concerning neurodegenerative disorders, particularly Parkinson's disease.

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    Out of stock

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  • Aminoquinol phosphate
    Cat. No.
    A84708
    CAS No.
    7195-12-2

    Aminoquinol phosphate

    Synonyms: (E/Z)-XIB4035 phosphate

    Aminoquinol phosphate is a GFRα-1 agonist that mimics the neurotrophic effects of glial cell-derived neurotrophic factor (GDNF). This compound induces Ret autophosphorylation in Neuro-2A cells, highlighting its potential role in neuroprotection. Aminoquinol phosphate is suitable for research applications related to Parkinson's disease and other neurodegenerative disorders, offering insights into mechanisms of neuronal survival and growth.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • Aminoquinol triphosphate
    Cat. No.
    A84709
    CAS No.
    3653-53-0

    Aminoquinol triphosphate

    Synonyms: (E/Z)-XIB4035 triphosphate

    Aminoquinol triphosphate is a potent GFRα-1 agonist that induces neurotrophic effects akin to Glial Cell-Derived Neurotrophic Factor (GDNF). This compound promotes Ret autophosphorylation in Neuro-2A cells, making it a valuable tool in research focused on neurodegenerative disorders, particularly Parkinson's disease. Its mechanism of action positions it as a promising candidate for studies exploring neuroprotection and neuronal survival.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

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