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IGF-1R

IGF-1R inhibitors act on the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase. Its primary structure, reported in 1986, revealed close homology with the insulin receptor, especially in the tyrosine kinase domain. Insulin-like growth factors I and II activate the receptor, which signals through the phosphoinositide 3-kinase (PI3K) and Akt pathway. The two receptors are so similar that many inhibitors in this set also act on the insulin receptor. NVP-AEW541, characterized in 2004, discriminates IGF-1R from the insulin receptor in cellular assays. Linsitinib, BMS-754807 and PQ 401 are further IGF-1R inhibitors, and the Insulin Receptor category lists related compounds.

3 Items

  • Ginsenoside Rg5
    Cat. No.
    A15613
    CAS No.
    186763-78-0

    Ginsenoside Rg5

    Ginsenoside Rg5 is a potent IGF-1R agonist primarily derived from Red ginseng. It functions by competing at the IGF-1 binding site on IGF-1R, effectively obstructing IGF-1's interaction and exhibiting an IC50 of approximately 90 nM. Additionally, Ginsenoside Rg5 downregulates COX-2 mRNA expression through inhibition of NF-κB p65 DNA binding activities, making it valuable for research into inflammation and metabolic regulation.

    In stock View Details
    1 mg
    $90.00
    5 mg
    $230.00
    All 6 sizes
  • [D-Ala2]-GIP (human)
    Cat. No.
    A23067
    CAS No.
    444073-04-5

    [D-Ala2]-GIP (human)

    [D-Ala2]-GIP (human) is a GIP receptor agonist. [D-Ala2]-GIP (human) improves glucose tolerance. [D-Ala2]-GIP (human) shows neuroprotective activity in MPTP-induced Parkinson's disease model. [D-Ala2]-GIP (human) also improves cognitive function and hippocampal synaptic plasticity in obese diabetic rats. [D-Ala2]-GIP (human) can be used for research of type 2 diabetes, Parkinson's disease, etc

    In stock View Details
    1 mg
    $415.00
    5 mg
    $835.00
    All 6 sizes
  • DA-JC4
    Cat. No.
    A23157
    CAS No.
    2315504-40-4

    DA-JC4

    DA-JC4 is a dual GLP-1/GIP receptor agonist and can be used for the research of neurological disease and insulin signaling pathways.

    In stock View Details
    1 mg
    $405.00
    5 mg
    $750.00
    All 2 sizes

3 Items

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