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Insulin Receptor

Insulin receptor inhibitors act on the tyrosine kinase receptor that relays insulin signals into cells. Two groups reported the human insulin receptor sequence in 1985 and placed it in the tyrosine kinase family of oncogenes. The receptor is a disulfide-linked dimer of alpha and beta subunits, and insulin binding triggers autophosphorylation of the beta subunits. Insulin receptor substrate proteins then couple the kinase to glucose uptake, glycogen synthesis and cell growth. Most compounds here are dual inhibitors that block the insulin receptor together with the insulin-like growth factor 1 receptor (IGF-1R). Examples are BMS-536924, GSK1904529A and AG-1024, while NVP-TAE 226 also inhibits focal adhesion kinase (FAK).

2 Items

  • DA-JC4
    Cat. No.
    A23157
    CAS No.
    2315504-40-4

    DA-JC4

    DA-JC4 is a dual GLP-1/GIP receptor agonist and can be used for the research of neurological disease and insulin signaling pathways.

    In stock View Details
    1 mg
    $405.00
    5 mg
    $750.00
    All 2 sizes
  • Insulin efsitora alfa
    Cat. No.
    A33749
    CAS No.
    2131038-11-2

    Insulin efsitora alfa

    Synonyms: LY-3209590

    Insulin efsitora alfa is a selective agonist of the insulin receptor (IR) designed to enhance insulin signaling. This fusion protein, which combines human insulin receptor agonists with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2), has a molecular weight of 64.1 kDa. Insulin efsitora alfa exhibits promising biological activity in modulating glucose metabolism and has potential applications in the treatment of diabetes and related metabolic disorders.

    In stock View Details
    0.5 mg
    $325.00
    1 mg
    $340.00
    All 3 sizes

2 Items

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