Reveromycin B is a spiroketal bacterial metabolite that targets epidermal growth factor (EGF) signaling. It effectively inhibits EGF-induced mitogenic activity in Balb/MK cells with an IC50 of 6 μg/mL. Additionally, Reveromycin B displays pH-dependent antifungal properties against Candida albicans, with minimum inhibitory concentrations (MICs) of 15.6 μg/mL at pH 3.0 and greater than 500 μg/mL at pH 7.4, while showing no inhibitory effect on the proliferation of KB and K562 cells. This compound is useful for studying EGF signaling pathways and exploring antifungal mechanisms.
Reveromycin B is a spiroketal bacterial metabolite that targets epidermal growth factor (EGF) signaling. It effectively inhibits EGF-induced mitogenic activity in Balb/MK cells with an IC50 of 6 μg/mL. Additionally, Reveromycin B displays pH-dependent antifungal properties against Candida albicans, with minimum inhibitory concentrations (MICs) of 15.6 μg/mL at pH 3.0 and greater than 500 μg/mL at pH 7.4, while showing no inhibitory effect on the proliferation of KB and K562 cells. This compound is useful for studying EGF signaling pathways and exploring antifungal mechanisms.
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