Steffimycin B is an anthracycline bacterial metabolite derived from Streptomyces, possessing a primary mechanism of DNA binding through preferential intercalation at cytosine and guanine-rich regions. It exhibits significant cytotoxicity against various cell lines, including MCF-7, KB, NCI-H187, and Vero cells, with IC50 values of 3.5, 6.75, 3.28, and 10.5 μM, respectively. Furthermore, Steffimycin B demonstrates potent antimicrobial activity against Mycobacterium tuberculosis (MIC=5.2 nM), Bacillus cereus (MIC=1.56 μg/mL), and Plasmodium falciparum (IC50=2.19 μM), making it a valuable compound for research in cancer and infectious diseases.
Steffimycin B is an anthracycline bacterial metabolite derived from Streptomyces, possessing a primary mechanism of DNA binding through preferential intercalation at cytosine and guanine-rich regions. It exhibits significant cytotoxicity against various cell lines, including MCF-7, KB, NCI-H187, and Vero cells, with IC50 values of 3.5, 6.75, 3.28, and 10.5 μM, respectively. Furthermore, Steffimycin B demonstrates potent antimicrobial activity against Mycobacterium tuberculosis (MIC=5.2 nM), Bacillus cereus (MIC=1.56 μg/mL), and Plasmodium falciparum (IC50=2.19 μM), making it a valuable compound for research in cancer and infectious diseases.
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