Ilicicolin F is a fungal metabolite that primarily targets bacterial oxidases, specifically inhibiting T. vivax alternative oxidase and E. coli ubiquinol oxidase cytochrome bo, with IC50 values of 0.43 and 0.37 μM, respectively. It exhibits antifungal activity against Aspergillus fumigatus and Candida albicans, demonstrating minimum inhibitory concentrations ranging from 1.66 to 13.33 μg/mL. Additionally, Ilicicolin F displays significant cytotoxicity in HeLa cells, with an EC50 value of 0.003 μg/mL, making it a potent candidate for research in microbial and cancer studies.
Ilicicolin F is a fungal metabolite that primarily targets bacterial oxidases, specifically inhibiting T. vivax alternative oxidase and E. coli ubiquinol oxidase cytochrome bo, with IC50 values of 0.43 and 0.37 μM, respectively. It exhibits antifungal activity against Aspergillus fumigatus and Candida albicans, demonstrating minimum inhibitory concentrations ranging from 1.66 to 13.33 μg/mL. Additionally, Ilicicolin F displays significant cytotoxicity in HeLa cells, with an EC50 value of 0.003 μg/mL, making it a potent candidate for research in microbial and cancer studies.
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