SKLB-0124 is a selective degrader of Protein Arginine Methyltransferase 6 (PRMT6) with an IC50 of 1.6 μM. This compound induces proteasome-dependent degradation of PRMT6, resulting in significant inhibition of cell proliferation and the induction of apoptosis and cell cycle arrest. SKLB-0124 has demonstrated DC50 values of 15.4 μM in HCC827 cells and 16.4 μM in MDA-MB-435 cells, making it a valuable reagent for researching lung and breast cancer. It does not degrade PRMT1 or PRMT8, ensuring specificity in studies involving PRMT6.
SKLB-0124 is a selective degrader of Protein Arginine Methyltransferase 6 (PRMT6) with an IC50 of 1.6 μM. This compound induces proteasome-dependent degradation of PRMT6, resulting in significant inhibition of cell proliferation and the induction of apoptosis and cell cycle arrest. SKLB-0124 has demonstrated DC50 values of 15.4 μM in HCC827 cells and 16.4 μM in MDA-MB-435 cells, making it a valuable reagent for researching lung and breast cancer. It does not degrade PRMT1 or PRMT8, ensuring specificity in studies involving PRMT6.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
