Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order

Y-27632 2HCl

Catalog No.: A11001

ROCK Inhibitor

Y-27632 2HCl

Y-27632 2HCl Chemical Structure

CAS NO. 146986-50-7, 129830-38-2

Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).

Availability: In stock

Package Price Qty
5 mg
10 mg
25 mg
50 mg
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Sergio Pedraza-Arevalo, .et al. Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids, STAR Protoc, 2022, Aug 30;3(3):101656 PMID: 36092820
  • Ji-Hyun Lee, .et al. p57Kip2 imposes the reserve stem cell state of gastric chief cells, Cell Stem Cell, 2022, May 5; 29(5): 826-839 PMID: 35523142
  • Adam Pietrobon, .et al. Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes, Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
  • Sarkawt Hamad, .et al. High-efficient serum-free differentiation of endothelial cells from human iPS cells, Stem Cell Res Ther, 2022, Jun 11;13(1):251 PMID: 35690874
  • Stasia Krishtul, .et al. Development of a bioactive microencapsulation platform incorporating decellularized extracellular matrix to entrap human induced pluripotent stem cells for versatile biomedical applications, Polym Adv Technol, 2022, 33( 11): 3842-3852
  • Peter T Ruane, .et al. Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation, Hum Reprod, 2022, Apr 1;37(4):777-792 PMID: 35079788
  • Takayuki Miyoshi, .et al. Successful induction of human chemically induced liver progenitors with small molecules from damaged liver, J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
  • Ana-Maria Cujba, .et al. An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function, Cell Rep, 2022, Mar 1;38(9):110425 PMID: 35235779
  • Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
  • Antigoni Gogolou, .et al. Generating Enteric Nervous System Progenitors from Human Pluripotent Stem Cells, Curr Protoc, 2021, Jun;1(6):e137 PMID: 34102038
  • Tiago De Oliveira, .et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo, Cancers (Basel), 2021, Mar 2;S2451-9456(21)00095-7 PMID: 33671096
  • Denise Muller, .et al. Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas, BMC Med, 2021, Nov 16;19(1):300 PMID: 34781947
  • Ayumi Horikawa, .et al. A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox, PloS one, 2021, Jul 12;16(7):e0254373 PMID: 34252142
  • Hayato Mizuta, .et al. Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer, Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640
  • Scott Bell, .et al. Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells, Stem Cell Reports, 2021, Jul 13;16(7):1749-1762 PMID: 34214487
  • Shenyang Li, .et al. Effect of porcine corneal stromal extract on keratocytes from SMILE-derived lenticules, J Cell Mol Med, 2020, Dec 20;25(2):1207-1220 PMID: 33342057
  • Takao FUCHIGAMI, .et al. Ameloblastoma cell lines derived from different subtypes demonstrate distinct developmental patterns in a novel animal experimental model, J Appl Oral Sci, 2020, 28: e20190558 PMID: 32348439
  • Jing-Yu Lin, .et al. In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals, Cell Discov, 2020, 6: 20 PMID: 32284878
  • Yu Huang, .et al. Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors, Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060
  • XinYan, .et al. Establishment of CSUASOi001-A, a non-integrated induced pluripotent stem cell line from urine-derived cells of a Chinese patient carrying RS1 gene mutation, Stem Cell Res, 2019, May 17 PMID: 31141763
  • Daniela F. Duarte Campos, .et al. Corneal bioprinting utilizing collagen?\based bioinks and primary human keratocytes, J Biomed Mater Res A, 2019, April 22 PMID: 31012205
  • Scott Bell, .et al. Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons, Am J Hum Genet, 2019, May 2;104(5):815-834 PMID: 31031012
  • Ooi J, .et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects, Cell Rep, 2019, Feb 26;26(9):2494-2508 PMID: 30811996
  • Scott Bell, .et al. Disruption of GRIN2B Impairs Differentiation in Human Neurons, Stem Cell Reports, 2018, Jul 10; 11(1):183-196 PMID: 29937144
  • Christina Zarouchlioti, .et al. Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity, Am J Hum Genet, 2018, Apr 5; 102(4): 528-539 PMID: 29526280
  • Ai Takemoto, .et al. A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis, Sci Rep, 2017, 7: 42186 PMID: 28176852
  • Scott Bell, .et al. A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing, Stem Cells Transl Med, 2017, Mar; 6(3): 886-896 PMID: 28170165

Biological Activity

Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).
ROCK1 (p160ROCK) (Cell-free assay) ROCK2 (Cell-free assay)
140 nM(Ki)300 nM(Ki)
In vitro (25°C) DMSO Warmed: 61 mg/mL (190.46 mM)
Water 13 mg/mL (40.59 mM)
Ethanol Insoluble
In vivo saline 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.22 mL 156.1 mL 312.21 mL
0.5 mM 6.24 mL 31.22 mL 62.44 mL
1 mM 3.12 mL 15.61 mL 31.22 mL
5 mM 0.62 mL 3.12 mL 6.24 mL

*The above data is based on the productmolecular weight 320.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11001
Actions Inhibitor
CAS No. 146986-50-7, 129830-38-2
Formula C14H21N3O.2HCl
M. Wt 320.3
Purity >98%

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Y-27632 2HCl | Y-27632 2HCl Supplier | purchase | cost | manufacturer | order | distributor | buy 146986-50-7, 129830-38-2| 146986-50-7, 129830-38-2 Supplier | purchase 146986-50-7, 129830-38-2 | 146986-50-7, 129830-38-2 cost | 146986-50-7, 129830-38-2 manufacturer | order 146986-50-7, 129830-38-2 | 146986-50-7, 129830-38-2 distributor