Y-27632 2HCl

Catalog No.: A11001

ROCK Inhibitor

Y-27632 2HCl

Y-27632 2HCl Chemical Structure

CAS NO. 146986-50-7, 129830-38-2

Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$65.00
25 mg
$100.00
50 mg
$190.00
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  • Yu Huang, .et al. Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors, Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060
  • XinYan, .et al. Establishment of CSUASOi001-A, a non-integrated induced pluripotent stem cell line from urine-derived cells of a Chinese patient carrying RS1 gene mutation, Stem Cell Res, 2019, May 17 PMID: 31141763
  • Daniela F. Duarte Campos, .et al. Corneal bioprinting utilizing collagen‐based bioinks and primary human keratocytes, J Biomed Mater Res A, 2019, April 22 PMID: 31012205
  • Scott Bell, .et al. Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons, Am J Hum Genet, 2019, May 2;104(5):815-834 PMID: 31031012
  • Ooi J, .et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects, Cell Rep, 2019, Feb 26;26(9):2494-2508 PMID: 30811996
  • Scott Bell, .et al. Disruption of GRIN2B Impairs Differentiation in Human Neurons, Stem Cell Reports, 2018, Jul 10; 11(1):183-196 PMID: 29937144
  • Christina Zarouchlioti, .et al. Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity, Am J Hum Genet, 2018, Apr 5; 102(4): 528–539 PMID: 29526280
  • Ai Takemoto, .et al. A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis, Sci Rep, 2017, 7: 42186 PMID: 28176852
  • Scott Bell, .et al. A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing, Stem Cells Transl Med, 2017, Mar; 6(3): 886–896 PMID: 28170165

Biological Activity

Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).
Targets
ROCK1 (p160ROCK) (Cell-free assay) ROCK2 (Cell-free assay)
140 nM(Ki)300 nM(Ki)
In vitro (25°C) DMSO 64 mg/mL warmed (199.83 mM)
Water 14 mg/mL (43.71 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.22 mL 156.1 mL 312.21 mL
0.5 mM 6.24 mL 31.22 mL 62.44 mL
1 mM 3.12 mL 15.61 mL 31.22 mL
5 mM 0.62 mL 3.12 mL 6.24 mL

*The above data is based on the productmolecular weight 320.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11001
Actions Inhibitor
M. Wt 320.3
Formula C14H21N3O.2HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 146986-50-7, 129830-38-2
SMILES C[[email protected]](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

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