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Biological Activity
Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).
Targets
ROCK1 (p160ROCK) (Cell-free assay) | ROCK2 (Cell-free assay) | |||
140 nM(Ki) | 300 nM(Ki) |
In vitro (25°C) | DMSO | Warmed: 61 mg/mL (190.46 mM) | |
Water | 13 mg/mL (40.59 mM) | ||
Ethanol | Insoluble | ||
In vivo | saline | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 31.22 mL | 156.1 mL | 312.21 mL |
0.5 mM | 6.24 mL | 31.22 mL | 62.44 mL |
1 mM | 3.12 mL | 15.61 mL | 31.22 mL |
5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
*The above data is based on the productmolecular weight 320.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11001 |
---|---|
Actions | Inhibitor |
CAS No. | 146986-50-7, 129830-38-2 |
Formula | C14H21N3O.2HCl |
M. Wt | 320.3 |
Purity | >98% |
SMILES | C[[email protected]](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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