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Y-27632 2HCl

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ROCK Inhibitor

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Catalog No. A11001

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Y-27632 5mg A11001-5

Regular Price: €57.00

Special Price: €51.30

Y-27632 10mg A11001-10

Regular Price: €85.50

Special Price: €76.95

Y-27632 25mg A11001-25

Regular Price: €171.00

Special Price: €153.90

Y-27632 50mg A11001-50

Regular Price: €247.00

Special Price: €222.30

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).

Y-27632 2HCl

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Publications citing Adooq Products
Y-27632 2HCl Citations (5)
  • Ooi J, .et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects, Cell Rep, 2019, Feb 26;26(9):2494-2508 PMID: 30811996
  • Scott Bell, .et al. Disruption of GRIN2B Impairs Differentiation in Human Neurons, Stem Cell Reports, 2018, Jul 10; 11(1):183-196 PMID: 29937144
  • Christina Zarouchlioti, .et al. Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity, Am J Hum Genet, 2018, Apr 5; 102(4): 528每539 PMID: 29526280
  • Ai Takemoto, .et al. A critical role of platelet TGF-汕 release in podoplanin-mediated tumour invasion and metastasis, Sci Rep, 2017, 7: 42186 PMID: 28176852
  • Scott Bell, .et al. A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing, Stem Cells Transl Med, 2017, Mar; 6(3): 886每896 PMID: 28170165

Chemical Information

Catalog Num A11001
Actions Inhibitor
M. Wt 320.3
Formula C14H21N3O.2HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 146986-50-7, 129830-38-2
Synonyms N/A
SMILES C[[email protected]](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
Chemical Name trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride

Biological Activity

Description
Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).
Targets
ROCK1 (p160ROCK) (Cell-free assay) ROCK2 (Cell-free assay)
140 nM(Ki)300 nM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 64 mg/mL warmed (199.83 mM)
Water 14 mg/mL (43.71 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.22 mL 156.1 mL 312.21mL
0.5 mM 6.24 mL 31.22 mL 62.44 mL
1 mM 3.12 mL 15.61 mL 31.22 mL
5 mM 0.62 mL 3.12 mL 6.24 mL

*The above data is based on the productmolecular weight 320.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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