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- Sergio Pedraza-Arevalo, .et al. Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids, STAR Protoc, 2022, Aug 30;3(3):101656 PMID: 36092820
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Biological Activity
Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).
Targets
| ROCK1 (p160ROCK) (Cell-free assay) | ROCK2 (Cell-free assay) | |||
| 140 nM(Ki) | 300 nM(Ki) |
| In vitro (25°C) | DMSO | Warmed: 61 mg/mL (190.46 mM) | |
| Water | 13 mg/mL (40.59 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | saline | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.22 mL | 156.1 mL | 312.21 mL |
| 0.5 mM | 6.24 mL | 31.22 mL | 62.44 mL |
| 1 mM | 3.12 mL | 15.61 mL | 31.22 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
*The above data is based on the productmolecular weight 320.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11001 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 146986-50-7, 129830-38-2 |
| Formula | C14H21N3O.2HCl |
| M. Wt | 320.3 |
| Purity | >98% |
| SMILES | C[[email protected]](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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