RKI-1447

Catalog No.: A13067
ROCK1/ROCK2 inhibitor
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Grouped product items
Product Name Price Stock Qty
RKI-1447 5mg
$54.00
In stock
RKI-1447 10mg
$92.00
In stock
RKI-1447 25mg
$240.00
In stock
RKI-1447 50mg
$400.00
In stock
RKI-1447 10mM * 1mL in DMSO
$111.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Targets
Target Value
Product Information
Catalog Num A13067
Formula C16H14N4O2S
Molecular Weight 326.37
CAS Number 1342278-01-6
SMILES C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3
Synonyms RKI1447; RKI 1447. ROCK Inhibitor XIII
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 62 mg/mL (189.97 mM)
Water Insoluble
Ethanol Insoluble
In vivo 15% Captisol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.64 mL 153.2 mL 306.4 mL
0.5 mM 6.13 mL 30.64 mL 61.28 mL
1 mM 3.06 mL 15.32 mL 30.64 mL
5 mM 0.61 mL 3.06 mL 6.13 mL
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