Calcium Channels

Cat. No.

A66021

CAS No.

865433-00-7

Aladorian

Synonyms: ARM036; S44121

Aladorian (ARM036; S44121) is a non-peptidic stabilizer of the ryanodine receptor 2 (RyR2). It effectively stabilizes RyR2 channels, addressing abnormal Ca²⁺ handling in cardiomyocytes and improving Ca²⁺ homeostasis independently of dystrophin restoration. This compound has been shown to mitigate early cardiomyopathy and enhance left ventricular function in canine models of muscular dystrophy. Aladorian is valuable for research into heart failure, cardiomyopathies associated with Duchenne muscular dystrophy, and other forms of muscular dystrophy.

Cat. No.

A66257

CAS No.

1233219-11-8

Aladorian sodium

Synonyms: ARM036 sodium; S44121 sodium

Aladorian sodium is a non-peptidic stabilizer of the ryanodine receptor 2 (RyR2). It effectively stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes, thereby improving calcium homeostasis independent of dystrophin restoration. This compound has been shown to attenuate early cardiomyopathy and enhance left ventricular function in canine models of muscular dystrophy. Aladorian sodium is applicable in research related to heart failure, Duchenne muscular dystrophy-associated cardiomyopathy, and general muscular dystrophy.

Cat. No.

A66399

CAS No.

179469-40-0

PDDHV

PDDHV is a potent calcium absorption inducer that stimulates the vanillic acid receptor VR1, leading to increased influx of 45Ca2+. It effectively promotes 45Ca2+ uptake in rat dorsal root ganglion neurons with an EC50 of 70 nM and elicits calcium mobilization in VR1-transfected CHO cells with an EC50 of 125 nM. Additionally, PDDHV inhibits [3H]-resiniferatoxin binding to rat dorsal root ganglion membranes, showcasing its utility in calcium signaling research.

Cat. No.

A72471

CAS No.

807370-75-8

N-Lignoceroyl Taurine

N-Lignoceroyl Taurine is an endogenous metabolite and taurine conjugate of lignoceric acid, identified through lipidomic analysis of bovine brain. This compound exhibits distinct biological activity as a substrate for fatty acid amide hydrolase (FAAH), with levels significantly elevated in FAAH knockout mice, indicating a potential role in lipid metabolism. Additionally, N-Lignoceroyl Taurine has been shown to activate transient receptor potential (TRP) calcium channels, including TRPV1 and TRPV4, highlighting its relevance in neurobiology and cellular signaling research.

Cat. No.

A90347

CAS No.

135269-51-1

D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium

D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium acts as a Ca2+ inducer by enhancing extracellular calcium entry via the upregulation of voltage-gated calcium channels. This compound is instrumental in studies related to calcium signaling pathways and is often utilized in investigations of cellular processes influenced by calcium ions. It serves as a valuable reagent for researchers exploring the roles of calcium in various physiological and pathological contexts.