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Chemical Information
Catalog Num | A11179 |
---|---|
Actions | Inhibitor |
M. Wt | 279.25 |
Formula | C11H13N5O4 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 58131-57-0 |
Synonyms | NSC207895 |
SMILES code | CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-] |
Chemical Name | 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide |
Description |
NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation. |
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Targets |
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Solubility (25°C)* | In vitro | DMSO | 0.4 mg/mL (1.43 mM) |
---|---|---|---|
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Cat. No. | Product Name | Solubility(mg/mL) | ||
---|---|---|---|---|
Water | DMSO | Ethanol | ||
A10255 | ABT-737 | <1 mg/mL | 163 mg/mL | <1 mg/mL |
A10022 | ABT-263 (Navitoclax) | <1 mg/mL | 195 mg/mL | <1 mg/mL |
A10665 | Obatoclax mesylate (GX15-070) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
A10955 | TW-37 | <1 mg/mL | 115 mg/mL | 4 mg/mL |
A10984 | VX-765 | <1 mg/mL | 102 mg/mL | 102 mg/mL |
A11090 | PAC-1 | <1 mg/mL | 78 mg/mL | 16 mg/mL |
A10491 | JNJ 26854165 | <1 mg/mL | 66 mg/mL | 2 mg/mL |
A11931 | RITA (NSC 652287) | <1 mg/mL | 115 mg/mL | 4 mg/mL |
A10522 | Lenalidomide (CC-5013) | <1 mg/mL | 52 mg/mL | <1 mg/mL |
A10743 | Pomalidomide (CC-4047) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
A11163 | AT-406 | <1 mg/mL | 112 mg/mL | 112 mg/mL |
A11002 | YM155 | 89 mg/mL | 55 mg/mL | 6 mg/mL |
A10935 | Tipifarnib (Zarnestra) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
A10657 | Nutlin-3 | <1 mg/mL | 116 mg/mL | 116 mg/mL |
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