XL388

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mTOR inhibitor

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Catalog No. A12395

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
XL388 5mg A12395-5

Regular Price: $150.00

Special Price: $120.00

XL388 10mg A12395-10

Regular Price: $250.00

Special Price: $200.00

XL388 25mg A12395-25

Regular Price: $500.00

Special Price: $400.00

XL388 100mg A12395-100

Regular Price: $1,000.00

Special Price: $800.00

XL388 10mM * 1mL in DMSO A12395-10mM-D

Regular Price: $259.00

Special Price: $207.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).

XL388

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Publications citing Adooq Products

Chemical Information

Catalog Num A12395
Actions Inhibitor
M. Wt 455.5
Formula C23H22FN3O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1251156-08-7
Synonyms XL 388, XL-388
SMILES code CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N
Chemical Name (7-(6-aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone

Biological Activity

Description
XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).
Targets
Target Value
mTORC1IC50: 8nM
mTORIC50: 9.9nM
mTORC2IC50: 166nM
PI3KαIC50: >3μM
CYP2C9IC50: 10.6μM
CYP2C8IC50: >20μM
CYP2D6IC50: >20μM
CYP3A4IC50: 24.6μM

Solubility

Solubility (25°C) * In vitro DMSO 23 mg/mL (50.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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