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GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases.
Targets
| mTOR | PI3Kα | |||
| 3.8 nM(Ki) | ~3 μM(Ki) |
| In vitro | DMSO | 91 mg/mL (201.08 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 6 mg/mL (13.25 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.09 mL | 110.47 mL | 220.95 mL |
| 0.5 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.09 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
*The above data is based on the productmolecular weight 452.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11443 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 452.6 |
| Formula | C24H32N6O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1207360-89-1 |
| Synonyms | GDC 0349, RG7603 |
| SMILES | CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[[email protected]@H]5C |
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