Signaling Pathway
Product type
Important Notice: For research use only. We do not sell to patients.
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| Discription | GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. | |||||
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| Targets |
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| Cell Research |
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| Catalog Num | A11443 |
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| Formula | C24H32N6O3 |
| Molecular Weight | 452.6 |
| CAS Number | 1207360-89-1 |
| SMILES | CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C |
| Synonyms | GDC 0349, RG7603 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 79 mg/mL (174.56 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (11.04 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.09 mL | 110.47 mL | 220.95 mL |
| 0.5 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.09 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
