GDC-0349

Catalog No.: A11443

mTOR inhibitor

GDC-0349

GDC-0349 Chemical Structure

CAS NO. 1207360-89-1

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$180.00
25 mg
$450.00
50 mg
$780.00
10mM * 1mL in DMSO
$110.00
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Biological Activity

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases.
Targets
mTOR PI3Kα
3.8 nM(Ki)~3 μM(Ki)
In vitro DMSO 91 mg/mL (201.08 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (13.25 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.09 mL 110.47 mL 220.95 mL
0.5 mM 4.42 mL 22.09 mL 44.19 mL
1 mM 2.21 mL 11.05 mL 22.09 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11443
Actions Inhibitor
M. Wt 452.6
Formula C24H32N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1207360-89-1
Synonyms GDC 0349, RG7603
SMILES CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[[email protected]@H]5C

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