GDC-0349

Catalog No.: A11443
mTOR inhibitor
GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases.
Grouped product items
Size Price Stock Qty
2mg
$25.00
In stock
5mg
$55.00
In stock
10mg
$95.00
In stock
25mg
$215.00
In stock
50mg
$315.00
In stock
100mg
$480.00
In stock
10mM * 1mL in DMSO
$55.00
In stock
Bulk Size
Bulk Discount
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Biological Activity
Discription GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases.
Targets
Target Value
Cell Research
Cell Line Type Value Description References
Product Information
Catalog Num A11443
Formula C24H32N6O3
Molecular Weight 452.6
CAS Number 1207360-89-1
SMILES CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C
Synonyms GDC 0349, RG7603
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 79 mg/mL (174.56 mM)
Water Insoluble
Ethanol 5 mg/mL (11.04 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.09 mL 110.47 mL 220.95 mL
0.5 mM 4.42 mL 22.09 mL 44.19 mL
1 mM 2.21 mL 11.05 mL 22.09 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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