Apoptosis Inducers

Cat. No.

A13070

CAS No.

519055-62-0

Tasisulam (LY573636)

Synonyms: LY 573636

LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.

Cat. No.

A10077

CAS No.

5508-58-7

Andrographolide

Andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent.

Cat. No.

A14204

CAS No.

517-88-4

(-)-Alkannin

(-)-Alkannin is a potent apoptosis inducer, extracted from Alkanna tinctoria, and has demonstrated significant anticancer activity. It effectively arrests the cell cycle and triggers apoptotic processes in various cancer cell lines. Additionally, (-)-Alkannin contributes to the reduction of hepatic inflammation through modulation of the Rho-kinase pathway, making it a valuable tool for research in cancer biology and inflammation studies.

Cat. No.

A14364

CAS No.

1086-80-2

Lumichrome

Lumichrome is a photodegradation product of riboflavin that acts as an apoptosis inducer. It has been shown to inhibit the growth of human lung cancer cells and induce apoptosis through a p53-dependent mechanism. Additionally, Lumichrome serves as an inhibitor of the AKT/β-catenin signaling pathway, highlighting its potential utility in cancer research and therapeutic studies.

Cat. No.

A14457

CAS No.

751-03-1

Obacunone

Obacunone is a triterpenoid limonoid with potent apoptosis-inducing properties. It has demonstrated significant anticancer effects through the activation of programmed cell death pathways. Additionally, Obacunone offers protective benefits to retinal pigment epithelial (RPE) cells against oxidative damage caused by ultraviolet (UV) radiation, making it a valuable reagent for research in cancer biology and oxidative stress studies.

Cat. No.

A15080

CAS No.

697235-39-5

Episilvestrol

Episilvestrol is a derivative of Silvestrol, which can induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM).

Cat. No.

A15240

CAS No.

143360-00-3

SMIP004

SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells.

Cat. No.

A15330

CAS No.

418788-90-6

2,3-DCPE

2,3 DCPE displays anticancer agent properties and induces ERK activation.

Cat. No.

A15332

CAS No.

154554-41-3

CHM 1

CHM 1 is a potent, selective antitumor agent in human hepatocellular carcinoma in vitro.

Cat. No.

A15572

CAS No.

118525-40-9

Icaritin

Synonyms: Anhydroicaritin

Icaritin is a prenylflavonoid derivative that functions as an apoptosis inducer. It has demonstrated potent inhibitory effects on the proliferation of K562 cells, with an IC50 of 8 µM, and primary chronic myeloid leukemia (CML) cells, exhibiting IC50 values of 13.4 µM for CML-chronic phase and 18 µM for CML-blast crisis. Icaritin modulates critical signaling pathways, including MAPK/ERK/JNK and JAK2/STAT3/AKT, and has been shown to enhance osteogenesis, making it a valuable compound for research in cancer and regenerative medicine.

Cat. No.

A15584

CAS No.

131-12-4

Pimpinellin

Pimpinellin is an apoptosis inducer derived from Cyrtomium fortumei. It demonstrates significant antitumor activity by promoting apoptosis in tumor cells, thereby inhibiting cellular growth and proliferation. This compound has potential applications in cancer research, particularly in studies focused on mechanistic pathways of cell death and therapeutic strategies for tumor suppression.

Cat. No.

A15655

CAS No.

39026-92-1

9-Methoxycamptothecin

9-Methoxycamptothecin (MCPT) is a potent apoptosis inducer that exerts its antitumor effects primarily through the inhibition of topoisomerase enzymes. Derived from Camptotheca acuminata, MCPT effectively induces G2/M cell cycle arrest and promotes apoptosis in various cancer cell lines. This compound is valuable for research applications focused on understanding cancer biology and therapeutic strategies targeting apoptotic pathways.

Cat. No.

A15718

CAS No.

728-61-0

Linderalactone

Linderalactone is a sesquiterpene lactone that acts as an apoptosis inducer by modulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. This compound has been shown to effectively inhibit the proliferation of lung cancer A-549 cells, displaying an IC50 of 15 µM. Its unique mechanism makes Linderalactone a valuable tool for research in cancer biology and therapeutic development.

Cat. No.

A15735

CAS No.

79498-31-0

Glaucocalyxin A

Glaucocalyxin A is an ent-kauranoid diterpene derived from Rabdosia japonica var. This compound acts as an apoptosis inducer by inhibiting the nuclear translocation of Five-zinc finger Glis 1 (GLI1), effectively modulating the PI3K/Akt signaling pathway. Its notable antitumor properties make Glaucocalyxin A a valuable reagent for research in cancer biology, particularly in studies focused on osteosarcoma.

Cat. No.

A17231

CAS No.

16082-64-7

NUN82647

Synonyms: QBS

NUN82647, also known as QBS or 2-Amino-N-quinolin-8-yl-benzenesulfonamide, is an Inhibitor of cell cycle at G2 phase; apoptosis inducer.

Cat. No.

A17642

CAS No.

5578-73-4

Sanguinarine chloride

Synonyms: Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride

Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms.

Cat. No.

A17866

CAS No.

108-78-1

Melamine

Melamine is an orally active apoptosis inducer that targets multiple biological pathways. It is effective in inducing disease models in animals, particularly concerning male reproductive function through its effects on Sertoli cells. Additionally, melamine exhibits neurotoxic and nephrotoxic properties, making it useful for research on cognitive impairment and acute kidney injury. Its potential to induce bladder cancer and urinary stone models further establishes melamine as a valuable tool in toxicological and cancer research.

Cat. No.

A18132

CAS No.

938448-87-4

Bucladesine calcium

Synonyms: Dibutyryl cAMP calcium salt; DBcAMP calcium salt

Bucladesine calcium is a cell-permeable analog of cyclic AMP (cAMP), functioning as an apoptosis inducer primarily through the activation of cAMP-dependent protein kinase (PKA). By elevating intracellular cAMP levels, it inhibits phosphodiesterase (PDE) activity, thereby stabilizing cAMP concentrations and promoting apoptosis in targeted cells. This compound is widely utilized in research applications investigating cell signaling pathways, PKA-mediated processes, and mechanisms underlying programmed cell death.

Cat. No.

A18979

CAS No.

2326007-49-0

IV-23

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC).

Cat. No.

A22437

CAS No.

1775-97-9

Flavokawain B

Synonyms: Flavokavain B

Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines.

Cat. No.

A24889

CAS No.

191545-24-1

epi-Eriocalyxin A

epi-Eriocalyxin A is a diterpenoid compound that serves as an apoptosis inducer in colon cancer cells. It effectively inhibits the activation of ERK1/2 and JNK pathways, leading to the suppression of Bcl-2 expression. This compound is valuable for research focused on cancer treatment and the mechanisms of apoptosis.

Cat. No.

A25088

CAS No.

5756-24-1

Dimethyl tetrasulfide

Synonyms: 1,4-Dimethyltetrasulfane

Dimethyl tetrasulfide (1,4-Dimethyltetrasulfane) is an apoptosis inducer that specifically targets leukemia cells. It demonstrates cytotoxic effects by promoting the production of intracellular reactive oxygen species (ROS) and activating the caspase-3 enzyme. This compound is valuable for research into cancer therapies, particularly in the context of leukemia.

Cat. No.

A25134

CAS No.

79491-71-7

Euptox A

Synonyms: 9-Oxo-10,11-dehydroageraphorone

Euptox A (9-Oxo-10, 11-dehydroageraphorone) is a potent apoptosis inducer derived from the cadenine sesquiterpene found in Eupatorium adenophorum. It enhances the expression of apoptotic proteases, particularly caspase-10, in HeLa cells, leading to increased apoptotic activity. This compound is valuable for research into apoptosis mechanisms and potential therapeutic applications in cancer treatment.

Cat. No.

A25135

CAS No.

186379-49-7

MT-21

MT-21 is an apoptosis inducer that functions as an inhibitor of adenine nucleotide translocase. It triggers apoptosis by activating c-Jun N-terminal kinase (JNK) through the Krs/MST signaling pathway and facilitates the activation of caspase-3 via caspase-9. Additionally, MT-21 promotes the release of cytochrome c from mitochondria, making it a valuable reagent for investigating tumor biology and apoptotic mechanisms in cancer research.

Cat. No.

A25141

CAS No.

1331880-08-0

SM1044

SM1044 is a dihydroartemisinin (DHA) dimer that serves as an apoptosis inducer. It activates caspase pathways to effectively trigger apoptosis in RL95-2 and KLE cancer cell lines. Additionally, SM1044 demonstrates potent antiproliferative activity, with IC50 values below 3.6 μM across multiple cancer cell lines, including HEC-50, HEC-1-A, HEC-1-B, and AN3CA. Furthermore, SM1044 has been shown to inhibit tumor growth in RL95-2 xenograft mouse models, highlighting its potential utility in cancer research.