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IAP

Inhibitor of apoptosis (IAP) antagonists target proteins that restrain caspases and cell death signaling. X-linked inhibitor of apoptosis protein (XIAP) was shown in 1997 to inhibit caspases directly through its baculovirus IAP repeat (BIR) domains. The mitochondrial protein second mitochondria-derived activator of caspases (Smac) relieves this block by binding to IAPs. Most listed compounds are Smac mimetics, which cause autoubiquitination and loss of cellular IAP 1 and 2 (cIAP1, cIAP2). This activates nuclear factor kappa B (NF-κB) and cell death driven by tumor necrosis factor alpha (TNF-α). Birinapant, LCL-161, xevinapant and GDC-0152 are examples, and BV-6 acts on cIAP1, cIAP2 and XIAP. Embelin, a natural benzoquinone, is listed as an XIAP inhibitor.

4 Items

  • LCL-161
    Cat. No.
    A11928
    CAS No.
    1005342-46-0

    LCL-161

    LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.

    In stock View Details
    2 mg
    $55.00
    5 mg
    $75.00
    All 7 sizes
  • Birinapant
    Cat. No.
    A12738
    CAS No.
    1260251-31-7

    Birinapant (TL32711)

    Synonyms: TL-32711

    Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.

    In stock View Details
    2 mg
    $35.00
    5 mg
    $60.00
    All 7 sizes
  • GDC-0152
    Cat. No.
    A14135
    CAS No.
    873652-48-3

    GDC-0152

    GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $80.00
    All 7 sizes
  • CST626
    Cat. No.
    A24498
    CAS No.
    3033993-13-1

    CST626

    CST626 (Compound 9) is a pan-IAP degrader PROTAC that targets and degrades inhibitor of apoptosis proteins XIAP, cIAP1, and cIAP2 in MM.1S cells, with DC₅₀ values of 0.7 nM, 2.4 nM, and 6.2 nM, respectively.

    In stock View Details
    1 mg
    $360.00
    5 mg
    $1,080.00
    All 4 sizes

4 Items

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